Literature DB >> 16641472

Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic.

Christian Dokomajilar1, Samuel L Nsobya, Bryan Greenhouse, Philip J Rosenthal, Grant Dorsey.   

Abstract

Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.

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Year:  2006        PMID： 16641472      PMCID： PMC1472234          DOI： 10.1128/AAC.50.5.1893-1895.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.

Authors:  M B Reed; K J Saliba; S R Caruana; K Kirk; A F Cowman
Journal:  Nature       Date:  2000-02-24       Impact factor: 49.962

2.  Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study.

Authors:  F Nosten; M van Vugt; R Price; C Luxemburger; K L Thway; A Brockman; R McGready; F ter Kuile; S Looareesuwan; N J White
Journal:  Lancet       Date:  2000-07-22       Impact factor: 79.321

3.  Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp.

Authors:  Adithya Cattamanchi; Daniel Kyabayinze; Alan Hubbard; Philip J Rosenthal; Grant Dorsey
Journal:  Am J Trop Med Hyg       Date:  2003-02       Impact factor: 2.345

4.  In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem).

Authors:  Christin Sisowath; Johan Strömberg; Andreas Mårtensson; Mwinyi Msellem; Christine Obondo; Anders Björkman; José P Gil
Journal:  J Infect Dis       Date:  2005-02-08       Impact factor: 5.226

5.  The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin.

Authors:  M T Duraisingh; P Jones; I Sambou; L von Seidlein; M Pinder; D C Warhurst
Journal:  Mol Biochem Parasitol       Date:  2000-04-30       Impact factor: 1.759

6.  pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum.

Authors:  Rhys Hayward; Kevin J Saliba; Kiaran Kirk
Journal:  Mol Microbiol       Date:  2005-02       Impact factor: 3.501

7.  Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.

Authors:  Andreas Mårtensson; Johan Strömberg; Christin Sisowath; Mwinyi I Msellem; J Pedro Gil; Scott M Montgomery; Piero Olliaro; Abdullah S Ali; Anders Björkman
Journal:  Clin Infect Dis       Date:  2005-09-13       Impact factor: 9.079

Review 8.  Tolerance is the key to understanding antimalarial drug resistance.

Authors:  Ian M Hastings; William M Watkins
Journal:  Trends Parasitol       Date:  2006-01-10

9.  Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.

Authors:  Ric N Price; Anne-Catrin Uhlemann; Michele van Vugt; Al Brockman; Robert Hutagalung; Shalini Nair; Denae Nash; Pratap Singhasivanon; Tim J C Anderson; Sanjeev Krishna; Nicholas J White; François Nosten
Journal:  Clin Infect Dis       Date:  2006-04-26       Impact factor: 9.079

10.  Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.

Authors:  Ric N Price; Anne-Catrin Uhlemann; Alan Brockman; Rose McGready; Elizabeth Ashley; Lucy Phaipun; Rina Patel; Kenneth Laing; Sornchai Looareesuwan; Nicholas J White; François Nosten; Sanjeev Krishna
Journal:  Lancet       Date:  2004 Jul 31-Aug 6       Impact factor: 79.321
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  87 in total

1.  pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa: implications for efficacy of artemisinin combination therapies.

Authors:  Benoit Witkowski; Xavier Iriart; Patrice Njomnang Soh; Sandie Menard; Muriel Alvarez; Veronique Naneix-Laroche; Bruno Marchou; Jean-François Magnaval; Françoise Benoit-Vical; Antoine Berry
Journal:  J Clin Microbiol       Date:  2010-07-28       Impact factor: 5.948

2.  Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda.

Authors:  Frederick N Baliraine; Samuel L Nsobya; Jane Achan; James K Tibenderana; Ambrose O Talisuna; Bryan Greenhouse; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

3.  Molecular assessment of Plasmodium falciparum resistance to antimalarial drugs in Papua New Guinea using an extended ligase detection reaction fluorescent microsphere assay.

Authors:  Rina P M Wong; Harin Karunajeewa; Ivo Mueller; Peter Siba; Peter A Zimmerman; Timothy M E Davis
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

4.  Rational deployment of antimalarial drugs in Africa: should first-line combination drugs be reserved for paediatric malaria cases?

Authors:  Colin J Sutherland; Hamza Babiker; Margaret J Mackinnon; Lisa Ranford-Cartwright; Badria Babiker El Sayed
Journal:  Parasitology       Date:  2011-08-03       Impact factor: 3.234

5.  Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.

Authors:  Rajeev K Mehlotra; Gabriel Mattera; Moses J Bockarie; Jason D Maguire; J Kevin Baird; Yagya D Sharma; Michael Alifrangis; Grant Dorsey; Philip J Rosenthal; David J Fryauff; James W Kazura; Mark Stoneking; Peter A Zimmerman
Journal:  Antimicrob Agents Chemother       Date:  2008-04-14       Impact factor: 5.191

6.  Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.

Authors:  Samuel L Nsobya; Christian Dokomajilar; Moses Joloba; Grant Dorsey; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2007-06-11       Impact factor: 5.191

7.  Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.

Authors:  C T Happi; G O Gbotosho; O A Folarin; A Sowunmi; T Hudson; M O'Neil; W Milhous; D F Wirth; A M J Oduola
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191

8.  In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

Authors:  Leah Mwai; Steven M Kiara; Abdi Abdirahman; Lewa Pole; Anja Rippert; Abdi Diriye; Pete Bull; Kevin Marsh; Steffen Borrmann; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

Review 9.  Drug-resistant malaria - an insight.

Authors:  John E Hyde
Journal:  FEBS J       Date:  2007-09       Impact factor: 5.542

10.  Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro.

Authors:  Sant Muangnoicharoen; David J Johnson; Sornchai Looareesuwan; Srivicha Krudsood; Stephen A Ward
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191
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