Literature DB >> 17562798

Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.

Samuel L Nsobya1, Christian Dokomajilar, Moses Joloba, Grant Dorsey, Philip J Rosenthal.   

Abstract

Key parasite polymorphisms were assessed in subjects treated for malaria with artesunate-amodiaquine in Tororo, Uganda. For pfcrt, all of the isolates tested had the CVIET haplotype. For pfmdr1, 86Y and 1246Y were common at baseline and their prevalences were significantly higher in new isolates after therapy, indicating that treatment selected for mutations associated with a decreased response to amodiaquine.

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Year:  2007        PMID： 17562798      PMCID： PMC1932488          DOI： 10.1128/AAC.00012-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

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  47 in total

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