Literature DB >> 16622410

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

Marc Bühler1, Silvia Steiner, Fabio Mohn, Alexandra Paillusson, Oliver Mühlemann.   

Abstract

Inconsistent with prevailing models for nonsense-mediated mRNA decay (NMD) in mammals, the mRNA levels of immunoglobulin-mu (Ig-mu) genes with premature termination codons (PTCs) in the penultimate exon are still reduced by NMD when the intron furthest downstream is deleted. As in yeast, this exon junction complex-independent NMD of Ig-mu mRNAs depends on the distance between the termination codon and the poly(A) tail and suggests an evolutionarily conserved mode of PTC recognition.

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Year:  2006        PMID： 16622410     DOI： 10.1038/nsmb1081

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  126 in total

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Authors:  Joel G Belasco
Journal:  Nat Rev Mol Cell Biol       Date:  2010-06-03       Impact factor: 94.444

2.  Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns.

Authors:  Tara L Crabb; Bianca J Lam; Klemens J Hertel
Journal:  RNA       Date:  2010-07-07       Impact factor: 4.942

Review 3.  Mechanisms of deadenylation-dependent decay.

Authors:  Chyi-Ying A Chen; Ann-Bin Shyu
Journal:  Wiley Interdiscip Rev RNA       Date:  2010-09-15       Impact factor: 9.957

Review 4.  Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes.

Authors:  Søren Lykke-Andersen; Torben Heick Jensen
Journal:  Nat Rev Mol Cell Biol       Date:  2015-09-23       Impact factor: 94.444

Review 5.  The exon junction complex as a node of post-transcriptional networks.

Authors:  Hervé Le Hir; Jérôme Saulière; Zhen Wang
Journal:  Nat Rev Mol Cell Biol       Date:  2015-12-16       Impact factor: 94.444

Review 6.  Nonsense-mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome.

Authors:  Aparna Kishor; Sarah E Fritz; J Robert Hogg
Journal:  Wiley Interdiscip Rev RNA       Date:  2019-05-26       Impact factor: 9.957

7.  Targeting of aberrant mRNAs to cytoplasmic processing bodies.

Authors:  Ujwal Sheth; Roy Parker
Journal:  Cell       Date:  2006-06-16       Impact factor: 41.582

8.  A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.

Authors:  Isabelle Behm-Ansmant; David Gatfield; Jan Rehwinkel; Valérie Hilgers; Elisa Izaurralde
Journal:  EMBO J       Date:  2007-02-22       Impact factor: 11.598

9.  Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes.

Authors:  Marine Dehecq; Laurence Decourty; Abdelkader Namane; Caroline Proux; Joanne Kanaan; Hervé Le Hir; Alain Jacquier; Cosmin Saveanu
Journal:  EMBO J       Date:  2018-10-01       Impact factor: 11.598

Review 10.  Poly(A) binding proteins: are they all created equal?

Authors:  Dixie J Goss; Frida Esther Kleiman
Journal:  Wiley Interdiscip Rev RNA       Date:  2012-12-13       Impact factor: 9.957
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