Literature DB >> 16597897

Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles.

Katherine N Ward1, Hoe Nam Leong, Elisabeth P Nacheva, Julie Howard, Claire E Atkinson, Nicholas W S Davies, Paul D Griffiths, Duncan A Clark.   

Abstract

Six immunocompetent patients with human herpesvirus 6 (HHV-6) chromosomal integration had HHV-6 and beta-globin DNA quantified in various samples by PCR. The mean HHV-6 DNA concentration (log(10) copies/milliliter) in blood was 7.0 (>/=1 HHV-6 DNA copies/leukocyte), and in serum it was 5.3 (>/=1 HHV-6 DNA copies/lysed cell). The mean HHV-6 DNA load (log(10) copies)/hair follicle was 4.2 (>/=1 copies/hair follicle cell), demonstrating that viral integration is not confined to blood cells. The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration.

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Year:  2006        PMID： 16597897      PMCID： PMC1448653          DOI： 10.1128/JCM.44.4.1571-1574.2006

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  15 in total

Review 1.  The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent.

Authors:  K N Ward
Journal:  J Clin Virol       Date:  2005-03       Impact factor: 3.168

Review 2.  The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.

Authors:  U A Gompels; J Nicholas; G Lawrence; M Jones; B J Thomson; M E Martin; S Efstathiou; M Craxton; H A Macaulay
Journal:  Virology       Date:  1995-05-10       Impact factor: 3.616

3.  Unexpected occasional persistence of high levels of HHV-6 DNA in sera: detection of variants A and B.

Authors:  Katherine N Ward; Anton D Thiruchelvam; Xosé Couto-Parada
Journal:  J Med Virol       Date:  2005-08       Impact factor: 2.327

4.  A multiplex PCR assay for the simultaneous detection of human herpesvirus 6 and human herpesvirus 7, with typing of HHV-6 by enzyme cleavage of PCR products.

Authors:  I M Kidd; D A Clark; J A Bremner; D Pillay; P D Griffiths; V C Emery
Journal:  J Virol Methods       Date:  1998-01       Impact factor: 2.014

5.  Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children.

Authors:  Mary T Caserta; Michael P McDermott; Stephen Dewhurst; Kenneth Schnabel; Jennifer A Carnahan; Lynne Gilbert; Gladys Lathan; Geraldine K Lofthus; Caroline B Hall
Journal:  J Pediatr       Date:  2004-10       Impact factor: 4.406

6.  Quantification of human herpesvirus 6 in immunocompetent persons and post-mortem tissues from AIDS patients by PCR.

Authors:  D A Clark; M Ait-Khaled; A C Wheeler; I M Kidd; J E McLaughlin; M A Johnson; P D Griffiths; V C Emery
Journal:  J Gen Virol       Date:  1996-09       Impact factor: 3.891

7.  Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA.

Authors:  M Luppi; R Marasca; P Barozzi; S Ferrari; L Ceccherini-Nelli; G Batoni; E Merelli; G Torelli
Journal:  J Med Virol       Date:  1993-05       Impact factor: 2.327

8.  Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA.

Authors:  Keiko Tanaka-Taya; Junji Sashihara; Hiroki Kurahashi; Kiyoko Amo; Hiromi Miyagawa; Kazuhiro Kondo; Shintaro Okada; Koichi Yamanishi
Journal:  J Med Virol       Date:  2004-07       Impact factor: 2.327

9.  Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis.

Authors:  Duncan A Clark; Elisabeth P Nacheva; Hoe Nam Leong; Diana Brazma; Ying Ting Li; Edward H F Tsao; Hubertus C E Buyck; Claire E Atkinson; Heather M Lawson; Michael N Potter; Paul D Griffiths
Journal:  J Infect Dis       Date:  2006-02-22       Impact factor: 5.226

10.  Targeted integration of human herpesvirus 6 in the p arm of chromosome 17 of human peripheral blood mononuclear cells in vivo.

Authors:  G Torelli; P Barozzi; R Marasca; P Cocconcelli; E Merelli; L Ceccherini-Nelli; S Ferrari; M Luppi
Journal:  J Med Virol       Date:  1995-07       Impact factor: 2.327
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  45 in total

1.  Quantitative HHV-6B antigenemia test for the monitoring of transplant patients.

Authors:  R Loginov; T Karlsson; K Höckerstedt; D Ablashi; I Lautenschlager
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-04-21       Impact factor: 3.267

2.  Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis.

Authors:  Katherine N Ward; Hoe Nam Leong; Anton D Thiruchelvam; Claire E Atkinson; Duncan A Clark
Journal:  J Clin Microbiol       Date:  2007-01-17       Impact factor: 5.948

Review 3.  Heterogeneous pathways of maternal-fetal transmission of human viruses (review).

Authors:  A Saleh Younes; Márta Csire; Beatrix Kapusinszky; Katalin Szomor; Mária Takács; György Berencsi
Journal:  Pathol Oncol Res       Date:  2009-09       Impact factor: 3.201

4.  Detection of HHV-6B in post-mortem central nervous system tissue of a post-bone marrow transplant recipient: a multi-virus array analysis.

Authors:  Karen Yao; Nahid Akyani; Donatella Donati; Naomi Sengamalay; Julie Fotheringham; Elodie Ghedin; Michael Bishop; John Barrett; Fatah Kashanchi; Steven Jacobson
Journal:  J Clin Virol       Date:  2006-12       Impact factor: 3.168

5.  Chromosomal integration of the HHV-6 genome as a possible cause of persistent HHV-6 detection in a patient with langerhans cell histiocytosis.

Authors:  Volker Strenger; Christian Urban
Journal:  Pathol Oncol Res       Date:  2010-03       Impact factor: 3.201

6.  Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective.

Authors:  Marcie Tomblyn; Tom Chiller; Hermann Einsele; Ronald Gress; Kent Sepkowitz; Jan Storek; John R Wingard; Jo-Anne H Young; Michael J Boeckh; Michael A Boeckh
Journal:  Biol Blood Marrow Transplant       Date:  2009-10       Impact factor: 5.742

Review 7.  Laboratory and clinical aspects of human herpesvirus 6 infections.

Authors:  Henri Agut; Pascale Bonnafous; Agnès Gautheret-Dejean
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

Review 8.  Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know.

Authors:  M Ogata; T Fukuda; T Teshima
Journal:  Bone Marrow Transplant       Date:  2015-04-27       Impact factor: 5.483

9.  Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus.

Authors:  Caroline Breese Hall; Mary T Caserta; Kenneth C Schnabel; Lynne M Shelley; Jennifer A Carnahan; Andrea S Marino; Christina Yoo; Geraldine K Lofthus
Journal:  J Infect Dis       Date:  2010-02-15       Impact factor: 5.226

10.  Human herpesvirus 6 meningoradiculitis treated with intravenous immunoglobulin and valganciclovir.

Authors:  Chafic Karam; Manuel Revuelta; Daniel Macgowan
Journal:  J Neurovirol       Date:  2008-09-23       Impact factor: 2.643
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