Literature DB >> 16593078

Molecular engineering: An approach to the development of general capabilities for molecular manipulation.

K E Drexler1.   

Abstract

Development of the ability to design protein molecules will open a path to the fabrication of devices to complex atomic specifications, thus sidestepping obstacles facing conventional microtechnology. This path will involve construction of molecular machinery able to position reactive groups to atomic precision. It could lead to great advances in computational devices and in the ability to manipulate biological materials. The existence of this path has implications for the present.

Year:  1981        PMID: 16593078      PMCID: PMC348724          DOI: 10.1073/pnas.78.9.5275

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  6 in total

1.  Protein-folding dynamics.

Authors:  M Karplus; D L Weaver
Journal:  Nature       Date:  1976-04-01       Impact factor: 49.962

2.  Dynamics of folded proteins.

Authors:  J A McCammon; B R Gelin; M Karplus
Journal:  Nature       Date:  1977-06-16       Impact factor: 49.962

3.  Genetic control of mutation rates in bacteriophageT4.

Authors:  J W Drake; E F Allen; S A Forsberg; R M Preparata; E O Greening
Journal:  Nature       Date:  1969-03-22       Impact factor: 49.962

4.  Three-dimensional molecular modeling and drug design.

Authors:  P Gund; J D Andose; J B Rhodes; G M Smith
Journal:  Science       Date:  1980-06-27       Impact factor: 47.728

5.  Chemical DNA synthesis and recombinant DNA studies.

Authors:  K Itakura; A D Riggs
Journal:  Science       Date:  1980-09-19       Impact factor: 47.728

6.  Design, synthesis and characterisation of a 34-residue polypeptide that interacts with nucleic acids.

Authors:  B Gutte; M Däumigen; E Wittschieber
Journal:  Nature       Date:  1979-10-25       Impact factor: 49.962

  6 in total
  53 in total

1.  Protein topology and stability define the space of allowed sequences.

Authors:  Patrice Koehl; Michael Levitt
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

2.  Computational protein design is a challenge for implicit solvation models.

Authors:  Alfonso Jaramillo; Shoshana J Wodak
Journal:  Biophys J       Date:  2004-09-17       Impact factor: 4.033

Review 3.  Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.

Authors:  Rolando E Yanes; Fuyuhiko Tamanoi
Journal:  Ther Deliv       Date:  2012-03

Review 4.  Biomolecular rods and tubes in nanotechnology.

Authors:  Alexander M Bittner
Journal:  Naturwissenschaften       Date:  2005-02

5.  Action-at-a-distance interactions enhance protein binding affinity.

Authors:  Brian A Joughin; David F Green; Bruce Tidor
Journal:  Protein Sci       Date:  2005-03-31       Impact factor: 6.725

6.  Protein WISDOM: a workbench for in silico de novo design of biomolecules.

Authors:  James Smadbeck; Meghan B Peterson; George A Khoury; Martin S Taylor; Christodoulos A Floudas
Journal:  J Vis Exp       Date:  2013-07-25       Impact factor: 1.355

7.  HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.

Authors:  Michael D Altman; Akbar Ali; G S Kiran Kumar Reddy; Madhavi N L Nalam; Saima Ghafoor Anjum; Hong Cao; Sripriya Chellappan; Visvaldas Kairys; Miguel X Fernandes; Michael K Gilson; Celia A Schiffer; Tariq M Rana; Bruce Tidor
Journal:  J Am Chem Soc       Date:  2008-04-16       Impact factor: 15.419

8.  Plenty of room, plenty of history.

Authors:  Chris Toumey
Journal:  Nat Nanotechnol       Date:  2009-12       Impact factor: 39.213

9.  Computational protein design and large-scale assessment by I-TASSER structure assembly simulations.

Authors:  Andrea Bazzoli; Andrea G B Tettamanzi; Yang Zhang
Journal:  J Mol Biol       Date:  2011-02-15       Impact factor: 5.469

Review 10.  [Use of nanoparticles in ophthalomology].

Authors:  I Hahn; P Heiduschka; E Endl; N Eter
Journal:  Ophthalmologe       Date:  2011-09       Impact factor: 1.059

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