BACKGROUND: Positron emission tomography scanners with retractable septa allow both 3-dimensional (3D) and 2-dimensional (2D) acquisition modes. The study aim was to directly compare 2D and 3D acquisition modes for the evaluation of absolute myocardial blood flow (MBF) over a wide range of flow values. METHODS AND RESULTS: Instrumentation was used in 4 dogs to reduce the left circumflex artery lumen by greater than 75%. During infusion of adenosine, MBF was measured with both 2D and 3D dynamic acquisition and both oxygen 15 water and nitrogen 13 ammonia. Injected activities were 333 MBq and 111 MBq for 2D acquisition and 3D acquisition, respectively. Data were reconstructed by analytic methods, and MBF was assessed by use of an 18-segment model. MBF values ranged from 0.4 to 5.8 mL x g(-1) x min(-1) with O-15 water and from 0.3 to 3.9 mL x g(-1) x min(-1) with N-13 ammonia. No significant differences were observed in absolute MBF values obtained with the 2 acquisition modes, regardless of the flow tracer used. Two-dimensionally and three-dimensionally derived MBF values were significantly strongly correlated by use of both O-15 water (y = 0.98x + 0.18, r = 0.87, P < .001) and N-13 ammonia (y = 0.99x + 0.09, r = 0.95, P < .001). CONCLUSION: Quantification of MBF in dogs with 3D positron emission tomography provides results similar to those obtained with the 2D technique, despite a lower activity being injected.
BACKGROUND: Positron emission tomography scanners with retractable septa allow both 3-dimensional (3D) and 2-dimensional (2D) acquisition modes. The study aim was to directly compare 2D and 3D acquisition modes for the evaluation of absolute myocardial blood flow (MBF) over a wide range of flow values. METHODS AND RESULTS: Instrumentation was used in 4 dogs to reduce the left circumflex artery lumen by greater than 75%. During infusion of adenosine, MBF was measured with both 2D and 3D dynamic acquisition and both oxygen 15 water and nitrogen 13 ammonia. Injected activities were 333 MBq and 111 MBq for 2D acquisition and 3D acquisition, respectively. Data were reconstructed by analytic methods, and MBF was assessed by use of an 18-segment model. MBF values ranged from 0.4 to 5.8 mL x g(-1) x min(-1) with O-15 water and from 0.3 to 3.9 mL x g(-1) x min(-1) with N-13 ammonia. No significant differences were observed in absolute MBF values obtained with the 2 acquisition modes, regardless of the flow tracer used. Two-dimensionally and three-dimensionally derived MBF values were significantly strongly correlated by use of both O-15 water (y = 0.98x + 0.18, r = 0.87, P < .001) and N-13 ammonia (y = 0.99x + 0.09, r = 0.95, P < .001). CONCLUSION: Quantification of MBF in dogs with 3D positron emission tomography provides results similar to those obtained with the 2D technique, despite a lower activity being injected.
Authors: Klaus P Schäfers; Terence J Spinks; Paolo G Camici; Peter M Bloomfield; Christopher G Rhodes; Marilyn P Law; Christopher S R Baker; Ornella Rimoldi Journal: J Nucl Med Date: 2002-08 Impact factor: 10.057
Authors: K Wienhard; M Dahlbom; L Eriksson; C Michel; T Bruckbauer; U Pietrzyk; W D Heiss Journal: J Comput Assist Tomogr Date: 1994 Jan-Feb Impact factor: 1.826
Authors: C A Nienaber; O Ratib; S S Gambhir; J Krivokapich; S C Huang; M E Phelps; H R Schelbert Journal: J Am Coll Cardiol Date: 1991-01 Impact factor: 24.094
Authors: Virginie Frings; Adrianus J de Langen; Maqsood Yaqub; Robert C Schuit; Astrid A M van der Veldt; Otto S Hoekstra; Egbert F Smit; Ronald Boellaard Journal: Mol Imaging Biol Date: 2014-02 Impact factor: 3.488