Literature DB >> 16579601

SPR imaging of photo-cross-linked small-molecule arrays on gold.

Naoki Kanoh1, Motoki Kyo, Kazuki Inamori, Ami Ando, Aya Asami, Aiko Nakao, Hiroyuki Osada.   

Abstract

Identification of small-molecule ligands for a protein of interest can facilitate the analysis of the protein's functions in biological systems. Small-molecule microarrays have allowed for rapid detection of such ligand-protein interactions in a high-throughput manner, although a label on a protein is needed to observe these interactions. By combining SPR imaging technology with our recently developed photo-cross-linked small-molecule array platform, we developed a novel platform that allows in situ observation of interactions between photo-cross-linked small molecules on gold surfaces and nonlabeled proteins in solution. Interactions of estrogenic and androgenic substances with estrogen receptor alpha were observed using this platform.

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Year:  2006        PMID： 16579601     DOI： 10.1021/ac051777j

Source DB:  PubMed          Journal:  Anal Chem        ISSN： 0003-2700            Impact factor:   6.986


  20 in total

Review 1.  Small-molecule microarrays as tools in ligand discovery.

Authors:  Arturo J Vegas; Jason H Fuller; Angela N Koehler
Journal:  Chem Soc Rev       Date:  2008-05-20       Impact factor: 54.564

2.  Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.

Authors:  Arturo J Vegas; James E Bradner; Weiping Tang; Olivia M McPherson; Edward F Greenberg; Angela N Koehler; Stuart L Schreiber
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

3.  Macromolecular scaffolds for immobilizing small molecule microarrays in label-free detection of protein-ligand interactions on solid support.

Authors:  Y S Sun; J P Landry; Y Y Fei; X D Zhu; J T Luo; X B Wang; K S Lam
Journal:  Anal Chem       Date:  2009-07-01       Impact factor: 6.986

4.  Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology.

Authors:  Shuai Zhao; Mo Yang; Wenfei Zhou; Baichao Zhang; Zhiqiang Cheng; Jiaxin Huang; Min Zhang; Zhiyou Wang; Rui Wang; Zhonglei Chen; Jinsong Zhu; Haitao Li
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-14       Impact factor: 11.205

Review 5.  Techniques for molecular imaging probe design.

Authors:  Fred Reynolds; Kimberly A Kelly
Journal:  Mol Imaging       Date:  2011-12       Impact factor: 4.488

6.  On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics.

Authors:  C Tassa; M Liong; S Hilderbrand; J E Sandler; T Reiner; E J Keliher; R Weissleder; S Y Shaw
Journal:  Lab Chip       Date:  2012-07-03       Impact factor: 6.799

Review 7.  Perfluorophenyl azides: new applications in surface functionalization and nanomaterial synthesis.

Authors:  Li-Hong Liu; Mingdi Yan
Journal:  Acc Chem Res       Date:  2010-08-06       Impact factor: 22.384

8.  The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.

Authors:  Makoto Kawatani; Hideo Okumura; Kaori Honda; Naoki Kanoh; Makoto Muroi; Naoshi Dohmae; Masamichi Takami; Mitsuhiro Kitagawa; Yushi Futamura; Masaya Imoto; Hiroyuki Osada
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-11       Impact factor: 11.205

9.  A localized surface plasmon resonance imaging instrument for multiplexed biosensing.

Authors:  Julia A Ruemmele; W Paige Hall; Laura K Ruvuna; Richard P Van Duyne
Journal:  Anal Chem       Date:  2013-04-19       Impact factor: 6.986

Review 10.  Recent discoveries and applications involving small-molecule microarrays.

Authors:  Jiyoung A Hong; Dylan V Neel; Dina Wassaf; Francisco Caballero; Angela N Koehler
Journal:  Curr Opin Chem Biol       Date:  2013-11-27       Impact factor: 8.822
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