Nina L Shapiro1, Neil Bhattacharyya. 1. Division of Head and Neck Surgery, UCLA School of Medicine, 90095, USA. nshapiro@ucla.edu
Abstract
OBJECTIVE: Determine presentation and survival rates for malignant pediatric salivary gland neoplasms. METHODS: All cases of malignant neoplasms involving the parotid or submandibular gland in patients ages birth to 18 years were extracted from the Surveillance, Epidemiology, and End Results database (1988-2001). Variables included age, gender, tumor histology, size, follow-up time, and vital status. Kaplan-Meier survival curves were constructed. RESULTS: 113 primary salivary gland malignancies (103 parotid, 10 submandibular) were identified. Mean age at presentation was 13.2 years. Female:male ratio of 5:4. Mean tumor size was 2.5 cm. Among parotid tumors, there were 44 (43%) mucoepidermoid carcinomas and 35 (34%) acinic cell carcinomas. At a mean follow-up of 69.4 months, 6 (5.8%) patients with parotid malignancy were deceased; none of the submandibular malignancies were fatal. Mean Kaplan-Meier survival for parotid gland lesions was 153 months, with rhabdomyosarcomas exhibiting significantly worse survivals as compared to other malignancies (P < 0.001, log-rank test). CONCLUSIONS: Both epithelial and mesenchymal tumors present in the pediatric salivary gland. Survival for both parotid and submandibular gland malignancies is good in children. EBM RATING: C-4.
OBJECTIVE: Determine presentation and survival rates for malignant pediatric salivary gland neoplasms. METHODS: All cases of malignant neoplasms involving the parotid or submandibular gland in patients ages birth to 18 years were extracted from the Surveillance, Epidemiology, and End Results database (1988-2001). Variables included age, gender, tumor histology, size, follow-up time, and vital status. Kaplan-Meier survival curves were constructed. RESULTS: 113 primary salivary gland malignancies (103 parotid, 10 submandibular) were identified. Mean age at presentation was 13.2 years. Female:male ratio of 5:4. Mean tumor size was 2.5 cm. Among parotid tumors, there were 44 (43%) mucoepidermoid carcinomas and 35 (34%) acinic cell carcinomas. At a mean follow-up of 69.4 months, 6 (5.8%) patients with parotid malignancy were deceased; none of the submandibular malignancies were fatal. Mean Kaplan-Meier survival for parotid gland lesions was 153 months, with rhabdomyosarcomas exhibiting significantly worse survivals as compared to other malignancies (P < 0.001, log-rank test). CONCLUSIONS: Both epithelial and mesenchymal tumors present in the pediatric salivary gland. Survival for both parotid and submandibular gland malignancies is good in children. EBM RATING: C-4.
Authors: Olga Micol Martínez; Elena Daghoum Dorado; María Dolores Amorós García; María Isabel Oviedo Ramírez; Isabel de la Fuente Muñoz; Jose Luis Fuster Soler Journal: Rare Tumors Date: 2016-10-06
Authors: Yusuf Kızıl; Utku Aydil; Ozgür Ekinci; Alper Dilci; Ahmet Köybaşıoğlu; Mehmet Düzlü; Erdoğan Inal Journal: Indian J Otolaryngol Head Neck Surg Date: 2012-11-10