Literature DB >> 16562870

Two new chiral EDTA-based metal chelates for weak alignment of proteins in solution.

Peter Haberz1, Fernando Rodriguez-Castañeda, Jochen Junker, Stefan Becker, Andrei Leonov, Christian Griesinger.   

Abstract

[structure: see text] A short synthesis of EDTA-based metal chelates that can be attached to the cysteine residue of a protein via a disulfide bond is described. The complexes were used after coordination of lanthanides to align trigger factor and apo-calmodulin in solution to yield residual dipolar couplings and pseudocontact shifts. Alignment tensors for the new tags are linearly independent compared to those of previously published tags.

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Year:  2006        PMID： 16562870     DOI： 10.1021/ol053049o

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  14 in total

1.  Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins.

Authors:  Hak Jun Kim; Stanley C Howell; Wade D Van Horn; Young Ho Jeon; Charles R Sanders
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2009-11-01       Impact factor: 9.795

2.  Engineering encodable lanthanide-binding tags into loop regions of proteins.

Authors:  Katja Barthelmes; Anne M Reynolds; Ezra Peisach; Hendrik R A Jonker; Nicholas J DeNunzio; Karen N Allen; Barbara Imperiali; Harald Schwalbe
Journal:  J Am Chem Soc       Date:  2011-02-02       Impact factor: 15.419

3.  Observation of microsecond time-scale protein dynamics in the presence of Ln3+ ions: application to the N-terminal domain of cardiac troponin C.

Authors:  Christian Eichmüller; Nikolai R Skrynnikov
Journal:  J Biomol NMR       Date:  2006-12-19       Impact factor: 2.835

4.  Two-point anchoring of a lanthanide-binding peptide to a target protein enhances the paramagnetic anisotropic effect.

Authors:  Tomohide Saio; Kenji Ogura; Masashi Yokochi; Yoshihiro Kobashigawa; Fuyuhiko Inagaki
Journal:  J Biomol NMR       Date:  2009-05-26       Impact factor: 2.835

Review 5.  Paramagnetic labelling of proteins and oligonucleotides for NMR.

Authors:  Xun-Cheng Su; Gottfried Otting
Journal:  J Biomol NMR       Date:  2009-06-16       Impact factor: 2.835

6.  How reliable are pseudocontact shifts induced in proteins and ligands by mobile paramagnetic metal tags? A modelling study.

Authors:  Dmitry Shishmarev; Gottfried Otting
Journal:  J Biomol NMR       Date:  2013-05-08       Impact factor: 2.835

7.  Convenient method for resolving degeneracies due to symmetry of the magnetic susceptibility tensor and its application to pseudo contact shift-based protein-protein complex structure determination.

Authors:  Yoshihiro Kobashigawa; Tomohide Saio; Masahiro Ushio; Mitsuhiro Sekiguchi; Masashi Yokochi; Kenji Ogura; Fuyuhiko Inagaki
Journal:  J Biomol NMR       Date:  2012-04-10       Impact factor: 2.835

8.  Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity.

Authors:  Fernando Rodríguez-Castañeda; Mitcheell Maestre-Martínez; Nicolas Coudevylle; Kalina Dimova; Harald Junge; Noa Lipstein; Donghan Lee; Stefan Becker; Nils Brose; Olaf Jahn; Teresa Carlomagno; Christian Griesinger
Journal:  EMBO J       Date:  2009-12-10       Impact factor: 11.598

9.  Prospects for lanthanides in structural biology by NMR.

Authors:  Gottfried Otting
Journal:  J Biomol NMR       Date:  2008-08-08       Impact factor: 2.835

10.  1H, 13C and 15N resonance assignments of the Calmodulin-Munc13-1 peptide complex.

Authors:  Fernando Rodríguez-Castañeda; Nicolas Coudevylle; Stefan Becker; Nils Brose; Teresa Carlomagno; Christian Griesinger
Journal:  Biomol NMR Assign       Date:  2009-12-15       Impact factor: 0.746
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