BACKGROUND: Although quality of life (QoL) and mental distress in women belonging to familial cancer families have been studied, little is known on these matters in women with absence of demonstrated mutations. The aim of this study was to examine QoL and cancer-related distress in such women. METHODS: About 330 women at risk for familial cancers in the absence of demonstrated mutations were invited to the study. About 239 women (72%) (risk group) completed the Short Form 12 (SF-12) and the Impact of Event Scale (IES). The SF-12-findings were compared to the age-adjusted findings from the general female population (controls). RESULTS: The risk group had significantly better physical QoL than controls, while no significant difference was found for mental QoL. Within the risk group the type of familial cancer did not make a significant difference in QoL, but to have a father with cancer or a deceased parent, was associated with increased risk of being a case with low QoL. Mental QoL showed moderate correlation with cancer-related distress. CONCLUSIONS: Women belonging to familial cancer families in the absence of demonstrated mutations had at least as good QoL as controls in spite of living with a permanent cancer-related threat.
BACKGROUND: Although quality of life (QoL) and mental distress in women belonging to familial cancer families have been studied, little is known on these matters in women with absence of demonstrated mutations. The aim of this study was to examine QoL and cancer-related distress in such women. METHODS: About 330 women at risk for familial cancers in the absence of demonstrated mutations were invited to the study. About 239 women (72%) (risk group) completed the Short Form 12 (SF-12) and the Impact of Event Scale (IES). The SF-12-findings were compared to the age-adjusted findings from the general female population (controls). RESULTS: The risk group had significantly better physical QoL than controls, while no significant difference was found for mental QoL. Within the risk group the type of familial cancer did not make a significant difference in QoL, but to have a father with cancer or a deceased parent, was associated with increased risk of being a case with low QoL. Mental QoL showed moderate correlation with cancer-related distress. CONCLUSIONS:Women belonging to familial cancer families in the absence of demonstrated mutations had at least as good QoL as controls in spite of living with a permanent cancer-related threat.
Authors: Sandra van Dijk; Christi J van Asperen; Catharina E Jacobi; Geraldine R Vink; Aad Tibben; Martijn H Breuning; Wilma Otten Journal: Genet Test Date: 2004
Authors: Sandra van Dijk; Wilma Otten; Daniëlle R M Timmermans; Christi J van Asperen; Hanne Meijers-Heijboer; Aad Tibben; Martijn H Breuning; Job Kievit Journal: Genet Med Date: 2005-04 Impact factor: 8.822
Authors: Pål Møller; Ake Borg; D Gareth Evans; Neva Haites; Marta M Reis; Hans Vasen; Elaine Anderson; C Michael Steel; Jaran Apold; David Goudie; Anthony Howell; Fiona Lalloo; Lovise Maehle; Helen Gregory; Ketil Heimdal Journal: Int J Cancer Date: 2002-10-20 Impact factor: 7.396