Literature DB >> 16511296

Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum.

Margaret A Holmes1, Frederick S Buckner, Wesley C Van Voorhis, Christopher Mehlin, Erica Boni, Thomas N Earnest, George DeTitta, Joseph Luft, Angela Lauricella, Lori Anderson, Oleksandr Kalyuzhniy, Frank Zucker, Lori W Schoenfeld, Wim G J Hol, Ethan A Merritt.   

Abstract

The structure of a conserved hypothetical protein, PlasmoDB sequence MAL13P1.257 from Plasmodium falciparum, Pfam sequence family PF05907, has been determined as part of the structural genomics effort of the Structural Genomics of Pathogenic Protozoa consortium. The structure was determined by multiple-wavelength anomalous dispersion at 2.17 A resolution. The structure is almost entirely beta-sheet; it consists of 15 beta-strands and one short 3(10)-helix and represents a new protein fold. The packing of the two monomers in the asymmetric unit indicates that the biological unit may be a dimer.

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Year:  2006        PMID： 16511296      PMCID： PMC2197184          DOI： 10.1107/S1744309106005847

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


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