Literature DB >> 16468065

Linear-no-threshold is a radiation-protection standard rather than a mechanistic effect model.

Joachim Breckow1.   

Abstract

The linear-no-threshold (LNT) controversy covers much more than the mere discussion whether or not "the LNT hypothesis is valid". It is shown that one cannot expect to find only one or even the only one dose-effect relationship. Each element within the biological reaction chain that is affected by ionizing radiation contributes in a specific way to the final biological endpoint of interest. The resulting dose-response relationship represents the superposition of all these effects. Till now there is neither a closed and clear picture of the entirety of radiation action for doses below some 10 mSv, nor does clear epidemiological evidence exist for an increase of risk for stochastic effects, in this dose range. On the other hand, radiation protection demands for quantitative risk estimates as well as for practicable dose concepts. In this respect, the LNT concept is preferred against any alternative concept. However, the LNT concept does not necessarily mean that the mechanism of cancer induction is intrinsically linear. It could hold even if the underlying multi-step mechanisms act in a non-linear way. In this case it would express a certain "attenuation" of non-linearities. Favouring LNT against threshold-, hyper-, or sub-linear models for radiation-protection purposes on the one hand, but preferring one of these models (e.g. for a specific effect) because of biological considerations for scientific purposes on the other hand, does not mean a contradiction.

Entities:  

Mesh:

Year:  2006        PMID: 16468065     DOI: 10.1007/s00411-006-0030-y

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN: 0301-634X            Impact factor:   1.925


  6 in total

1.  Radiation-related cancer risks at low doses among atomic bomb survivors.

Authors:  D A Pierce; D L Preston
Journal:  Radiat Res       Date:  2000-08       Impact factor: 2.841

2.  Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries.

Authors:  Amy Berrington de González; Sarah Darby
Journal:  Lancet       Date:  2004-01-31       Impact factor: 79.321

3.  Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies.

Authors:  S Darby; D Hill; A Auvinen; J M Barros-Dios; H Baysson; F Bochicchio; H Deo; R Falk; F Forastiere; M Hakama; I Heid; L Kreienbrock; M Kreuzer; F Lagarde; I Mäkeläinen; C Muirhead; W Oberaigner; G Pershagen; A Ruano-Ravina; E Ruosteenoja; A Schaffrath Rosario; M Tirmarche; L Tomásek; E Whitley; H-E Wichmann; R Doll
Journal:  BMJ       Date:  2004-12-21

4.  Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries.

Authors:  E Cardis; M Vrijheid; M Blettner; E Gilbert; M Hakama; C Hill; G Howe; J Kaldor; C R Muirhead; M Schubauer-Berigan; T Yoshimura; F Bermann; G Cowper; J Fix; C Hacker; B Heinmiller; M Marshall; I Thierry-Chef; D Utterback; Y-O Ahn; E Amoros; P Ashmore; A Auvinen; J-M Bae; J Bernar Solano; A Biau; E Combalot; P Deboodt; A Diez Sacristan; M Eklof; H Engels; G Engholm; G Gulis; R Habib; K Holan; H Hyvonen; A Kerekes; J Kurtinaitis; H Malker; M Martuzzi; A Mastauskas; A Monnet; M Moser; M S Pearce; D B Richardson; F Rodriguez-Artalejo; A Rogel; H Tardy; M Telle-Lamberton; I Turai; M Usel; K Veress
Journal:  BMJ       Date:  2005-06-29

5.  Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates.

Authors:  Dale L Preston; Donald A Pierce; Yukiko Shimizu; Harry M Cullings; Shoichiro Fujita; Sachiyo Funamoto; Kazunori Kodama
Journal:  Radiat Res       Date:  2004-10       Impact factor: 2.841

6.  Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997.

Authors:  Dale L Preston; Yukiko Shimizu; Donald A Pierce; Akihiko Suyama; Kiyohiko Mabuchi
Journal:  Radiat Res       Date:  2003-10       Impact factor: 2.841

  6 in total
  13 in total

1.  Whole body imaging in the diagnosis of blunt trauma, ionizing radiation hazards and residual risk.

Authors:  J P Kepros; R C Opreanu; R Samaraweera; A Briningstool; C A Morrison; B D Mosher; P Schneider; P Stevens
Journal:  Eur J Trauma Emerg Surg       Date:  2012-07-12       Impact factor: 3.693

2.  LNT: a never-ending story.

Authors:  Anna A Friedl; Werner Rühm
Journal:  Radiat Environ Biophys       Date:  2006-03       Impact factor: 1.925

3.  A perspective on the scientific, philosophical, and policy dimensions of hormesis.

Authors:  George R Hoffmann
Journal:  Dose Response       Date:  2009-01-19       Impact factor: 2.658

4.  Overestimation of Chernobyl consequences: biophysical aspects.

Authors:  Sergei V Jargin
Journal:  Radiat Environ Biophys       Date:  2009-04-07       Impact factor: 1.925

5.  The linear no-threshold relationship is inconsistent with radiation biologic and experimental data.

Authors:  Maurice Tubiana; Ludwig E Feinendegen; Chichuan Yang; Joseph M Kaminski
Journal:  Radiology       Date:  2009-04       Impact factor: 11.105

6.  Radiation-induced risks at low dose: moving beyond controversy towards a new vision.

Authors:  François Bréchignac; François Paquet
Journal:  Radiat Environ Biophys       Date:  2013-05-21       Impact factor: 1.925

7.  Chernobyl-level radiation exposure damages bumblebee reproduction: a laboratory experiment.

Authors:  Katherine E Raines; Penelope R Whitehorn; David Copplestone; Matthew C Tinsley
Journal:  Proc Biol Sci       Date:  2020-10-21       Impact factor: 5.349

8.  Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment.

Authors:  Alexander M Vaiserman
Journal:  Dose Response       Date:  2010-01-18       Impact factor: 2.658

9.  Fears, feelings, and facts: interactively communicating benefits and risks of medical radiation with patients.

Authors:  Lawrence T Dauer; Raymond H Thornton; Jennifer L Hay; Rochelle Balter; Matthew J Williamson; Jean St Germain
Journal:  AJR Am J Roentgenol       Date:  2011-04       Impact factor: 3.959

10.  Risk of leukaemia mortality from exposure to ionising radiation in US nuclear workers: a pooled case-control study.

Authors:  Robert D Daniels; Stephen Bertke; Kathleen M Waters; Mary K Schubauer-Berigan
Journal:  Occup Environ Med       Date:  2012-09-21       Impact factor: 4.402

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.