| Literature DB >> 16455252 |
Tomio Ishida1, Takayoshi Suzuki, Shintaro Hirashima, Kenji Mizutani, Atsuhito Yoshida, Izuru Ando, Satoru Ikeda, Tsuyoshi Adachi, Hiromasa Hashimoto.
Abstract
A series of 1-cycloalkyl-2-phenyl-1H-benzimidazole-5-carboxylic acid derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase (RdRp). A SAR study was performed and led to identify the 2-[(4-diarylmethoxy)phenyl]-benzimidazoles as potent inhibitors. They inhibit subgenomic HCV RNA replication in the replicon cells at low micromolar concentrations (EC(50) as low as 1.1microM). They are selective against DNA polymerases (IC(50)>10microM) and exhibit low cytotoxicity.Entities:
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Year: 2006 PMID： 16455252 DOI： 10.1016/j.bmcl.2006.01.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823