OBJECTIVE: To determine characteristics of transcranial magnetic stimulation (TMS)-induced measures of central motor excitability to the paretic and nonparetic quadriceps muscles of chronic hemiparetic stroke patients in the context of a short-term, submaximal bout treadmill exercise. DESIGN: Cross-sectional. SETTING: Motor control and gait biomechanics laboratory. PARTICIPANTS: Convenience sample of 11 patients including cohorts of treadmill untrained (n=8) and trained (n=3) stroke patients with chronic hemiparetic gait. INTERVENTION: Short-term submaximal treadmill exercise. MAIN OUTCOME MEASURES: Thresholds, amplitudes and latencies of TMS-induced motor evoked potentials at vastus medialis in paretic and nonparetic lower extremities. RESULTS: Baseline characteristics of the motor evoked potentials (MEPs) show significantly higher motor thresholds, longer latencies, and reduced amplitudes on the paretic side. In cross-sectional comparisons a group of treadmill-trained patients had greater paretic MEP amplitude changes after treadmill exercise versus paretic MEP responses from a group of untrained patients. CONCLUSIONS: These results indicate that treadmill training for 3 months or more may alter responsiveness of the lower-extremity central motor pathways to a short-term treadmill stimulus.
OBJECTIVE: To determine characteristics of transcranial magnetic stimulation (TMS)-induced measures of central motor excitability to the paretic and nonparetic quadriceps muscles of chronic hemiparetic strokepatients in the context of a short-term, submaximal bout treadmill exercise. DESIGN: Cross-sectional. SETTING: Motor control and gait biomechanics laboratory. PARTICIPANTS: Convenience sample of 11 patients including cohorts of treadmill untrained (n=8) and trained (n=3) strokepatients with chronic hemiparetic gait. INTERVENTION: Short-term submaximal treadmill exercise. MAIN OUTCOME MEASURES: Thresholds, amplitudes and latencies of TMS-induced motor evoked potentials at vastus medialis in paretic and nonparetic lower extremities. RESULTS: Baseline characteristics of the motor evoked potentials (MEPs) show significantly higher motor thresholds, longer latencies, and reduced amplitudes on the paretic side. In cross-sectional comparisons a group of treadmill-trained patients had greater paretic MEP amplitude changes after treadmill exercise versus paretic MEP responses from a group of untrained patients. CONCLUSIONS: These results indicate that treadmill training for 3 months or more may alter responsiveness of the lower-extremity central motor pathways to a short-term treadmill stimulus.
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