Literature DB >> 20187247

Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease.

Giselle M Petzinger1, Beth E Fisher, Jon-Eric Van Leeuwen, Marta Vukovic, Garnik Akopian, Charlie K Meshul, Daniel P Holschneider, Angelo Nacca, John P Walsh, Michael W Jakowec.   

Abstract

Epidemiological and clinical trials have suggested that exercise is beneficial for patients with Parkinson's disease (PD). However, the underlying mechanisms and potential for disease modification are currently unknown. This review presents current findings from our laboratories in patients with PD and animal models. The data indicate that alterations in both dopaminergic and glutamatergic neurotransmission, induced by activity-dependent (exercise) processes, may mitigate the cortically driven hyper-excitability in the basal ganglia normally observed in the parkinsonian state. These insights have potential to identify novel therapeutic treatments capable of reversing or delaying disease progression in PD.

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Year:  2010        PMID： 20187247      PMCID： PMC4111643          DOI： 10.1002/mds.22782

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  46 in total

1.  Failure analysis of stepping in adult spinal cats.

Authors:  R D de Leon; N J London; R R Roy; V R Edgerton
Journal:  Prog Brain Res       Date:  1999       Impact factor: 2.453

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Journal:  J Neurosci       Date:  1999-11-15       Impact factor: 6.167

Review 3.  Intracellular machinery for the transport of AMPA receptors.

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Journal:  Br J Pharmacol       Date:  2007-11-19       Impact factor: 8.739

4.  Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats.

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Journal:  Neuroimage       Date:  2007-03-23       Impact factor: 6.556

5.  Stereotactic pallidotomy lengthens the transcranial magnetic cortical stimulation silent period in Parkinson's disease.

Authors:  M S Young; W J Triggs; D Bowers; M Greer; W A Friedman
Journal:  Neurology       Date:  1997-11       Impact factor: 9.910

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Journal:  Neuroscience       Date:  1984-12       Impact factor: 3.590

7.  Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS.

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Journal:  Neuron       Date:  1995-07       Impact factor: 17.173

Review 8.  The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments.

Authors:  R K Schwarting; J P Huston
Journal:  Prog Neurobiol       Date:  1996-10       Impact factor: 11.685

9.  Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum.

Authors:  J J Bouyer; D H Park; T H Joh; V M Pickel
Journal:  Brain Res       Date:  1984-06-08       Impact factor: 3.252

Review 10.  Recovery from brain injury in animals: relative efficacy of environmental enrichment, physical exercise or formal training (1990-2002).

Authors:  Bruno Will; Rodrigue Galani; Christian Kelche; Mark R Rosenzweig
Journal:  Prog Neurobiol       Date:  2004-02       Impact factor: 11.685
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  63 in total

Review 1.  The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease.

Authors:  Gretchen O Reynolds; Michael W Otto; Terry D Ellis; Alice Cronin-Golomb
Journal:  Mov Disord       Date:  2015-12-30       Impact factor: 10.338

Review 2.  Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance.

Authors:  R Anne Stetler; Rehana K Leak; Yu Gan; Peiying Li; Feng Zhang; Xiaoming Hu; Zheng Jing; Jun Chen; Michael J Zigmond; Yanqin Gao
Journal:  Prog Neurobiol       Date:  2014-01-02       Impact factor: 11.685

3.  Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease.

Authors:  Giselle M Petzinger; Beth E Fisher; Sarah McEwen; Jeff A Beeler; John P Walsh; Michael W Jakowec
Journal:  Lancet Neurol       Date:  2013-07       Impact factor: 44.182

4.  The yeast product Milmed enhances the effect of physical exercise on motor performance and dopamine neurochemistry recovery in MPTP-lesioned mice.

Authors:  Trevor Archer; Anders Fredriksson
Journal:  Neurotox Res       Date:  2013-07-27       Impact factor: 3.911

5.  Progression of postural changes in Parkinson's disease: quantitative assessment.

Authors:  Alexander Khlebtovsky; Ruth Djaldetti; Yaniv Rodity; Ofir Keret; Gloria Tsvetov; Ilana Slutzcki-Shraga; Felix Benninger
Journal:  J Neurol       Date:  2017-02-02       Impact factor: 4.849

6.  Variability in cadence during forced cycling predicts motor improvement in individuals with Parkinson's disease.

Authors:  Angela L Ridgel; Hassan Mohammadi Abdar; Jay L Alberts; Fred M Discenzo; Kenneth A Loparo
Journal:  IEEE Trans Neural Syst Rehabil Eng       Date:  2012-10-24       Impact factor: 3.802

7.  Novel, high-intensity exercise prescription improves muscle mass, mitochondrial function, and physical capacity in individuals with Parkinson's disease.

Authors:  Neil A Kelly; Matthew P Ford; David G Standaert; Ray L Watts; C Scott Bickel; Douglas R Moellering; S Craig Tuggle; Jeri Y Williams; Laura Lieb; Samuel T Windham; Marcas M Bamman
Journal:  J Appl Physiol (1985)       Date:  2014-01-09

8.  A motor learning-based intervention to ameliorate freezing of gait in subjects with Parkinson's disease.

Authors:  Meir Plotnik; Shirley Shema; Moran Dorfman; Eran Gazit; Marina Brozgol; Nir Giladi; Jeffrey M Hausdorff
Journal:  J Neurol       Date:  2014-04-23       Impact factor: 4.849

9.  A two-year randomized controlled trial of progressive resistance exercise for Parkinson's disease.

Authors:  Daniel M Corcos; Julie A Robichaud; Fabian J David; Sue E Leurgans; David E Vaillancourt; Cynthia Poon; Miriam R Rafferty; Wendy M Kohrt; Cynthia L Comella
Journal:  Mov Disord       Date:  2013-03-27       Impact factor: 10.338

10.  Two-year exercise program improves physical function in Parkinson's disease: the PRET-PD randomized clinical trial.

Authors:  Janey Prodoehl; Miriam R Rafferty; Fabian J David; Cynthia Poon; David E Vaillancourt; Cynthia L Comella; Sue E Leurgans; Wendy M Kohrt; Daniel M Corcos; Julie A Robichaud
Journal:  Neurorehabil Neural Repair       Date:  2014-06-24       Impact factor: 3.919
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