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Literature DB >> 16388575

Pentapeptide repeat proteins.

Matthew W Vetting¹, Subray S Hegde, J Eduardo Fajardo, Andras Fiser, Steven L Roderick, Howard E Takiff, John S Blanchard.

Abstract

The pentapeptide repeat protein (PRP) family has more than 500 members in the prokaryotic and eukaryotic kingdoms. These proteins are composed of, or contain domains composed of, tandemly repeated amino acid sequences with a consensus sequence of [S,T,A,V][D,N][L,F][S,T,R][G]. The biochemical function of the vast majority of PRP family members is unknown. The three-dimensional structure of the first member of the PRP family was determined for the fluoroquinolone resistance protein (MfpA) from Mycobacterium tuberculosis. The structure revealed that the pentapeptide repeats encode the folding of a novel right-handed quadrilateral beta-helix. MfpA binds to DNA gyrase and inhibits its activity. The rod-shaped, dimeric protein exhibits remarkable similarity in size, shape, and electrostatics to DNA.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16388575 PMCID： PMC2566302 DOI： 10.1021/bi052130w

Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162

45 in total

1. Biochemical and functional characterization of a eukaryotic-type protein kinase, SpkB, in the cyanobacterium, Synechocystis sp. PCC 6803.

Authors: Ayako Kamei; Shizue Yoshihara; Takashi Yuasa; Xiaoxing Geng; Masahiko Ikeuchi
Journal: Curr Microbiol Date: 2003-04 Impact factor: 2.188

2. The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003.

Authors: Brigitte Boeckmann; Amos Bairoch; Rolf Apweiler; Marie-Claude Blatter; Anne Estreicher; Elisabeth Gasteiger; Maria J Martin; Karine Michoud; Claire O'Donovan; Isabelle Phan; Sandrine Pilbout; Michel Schneider
Journal: Nucleic Acids Res Date: 2003-01-01 Impact factor: 16.971

3. Origin of plasmid-mediated quinolone resistance determinant QnrA.

Authors: Laurent Poirel; Jose-Manuel Rodriguez-Martinez; Hedi Mammeri; Alain Liard; Patrice Nordmann
Journal: Antimicrob Agents Chemother Date: 2005-08 Impact factor: 5.191

4. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).

Authors: S D Bentley; K F Chater; A-M Cerdeño-Tárraga; G L Challis; N R Thomson; K D James; D E Harris; M A Quail; H Kieser; D Harper; A Bateman; S Brown; G Chandra; C W Chen; M Collins; A Cronin; A Fraser; A Goble; J Hidalgo; T Hornsby; S Howarth; C-H Huang; T Kieser; L Larke; L Murphy; K Oliver; S O'Neil; E Rabbinowitsch; M-A Rajandream; K Rutherford; S Rutter; K Seeger; D Saunders; S Sharp; R Squares; S Squares; K Taylor; T Warren; A Wietzorrek; J Woodward; B G Barrell; J Parkhill; D A Hopwood
Journal: Nature Date: 2002-05-09 Impact factor: 49.962

5. Mechanism of plasmid-mediated quinolone resistance.

Authors: John H Tran; George A Jacoby
Journal: Proc Natl Acad Sci U S A Date: 2002-04-09 Impact factor: 11.205

Review 6. Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae.

Authors: Patrice Nordmann; Laurent Poirel
Journal: J Antimicrob Chemother Date: 2005-07-14 Impact factor: 5.790

7. Plasmid-mediated resistance to ciprofloxacin and cefotaxime in clinical isolates of Salmonella enterica serotype Enteritidis in Hong Kong.

Authors: Terence Kin Man Cheung; Yiu Wai Chu; Man Yu Chu; Choi Ha Ma; Raymond Wai Hung Yung; Kai Man Kam
Journal: J Antimicrob Chemother Date: 2005-07-20 Impact factor: 5.790

8. Regulation of manganese uptake in Synechocystis 6803 by RfrA, a member of a novel family of proteins containing a repeated five-residues domain.

Authors: Leeann E Chandler; Victor V Bartsevich; Himadri B Pakrasi
Journal: Biochemistry Date: 2003-05-13 Impact factor: 3.162

Review 9. Fluoroquinolones: action and resistance.

Authors: Karl Drlica; Muhammad Malik
Journal: Curr Top Med Chem Date: 2003 Impact factor: 3.295

10. Cloning of the conserved regulatory operon by its aerial mycelium-inducing activity in an amfR mutant of Streptomyces griseus.

Authors: Mamoru Komatsu; Yoshitaka Kuwahara; Ayako Hiroishi; Kuniaki Hosono; Teruhiko Beppu; Kenji Ueda
Journal: Gene Date: 2003-03-13 Impact factor: 3.688

66 in total

1. The 1.7 Å resolution structure of At2g44920, a pentapeptide-repeat protein in the thylakoid lumen of Arabidopsis thaliana.

Authors: Shuisong Ni; Michael E McGookey; Stuart L Tinch; Alisha N Jones; Seetharaman Jayaraman; Liang Tong; Michael A Kennedy
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2011-11-25

2. Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor.

Authors: Subray S Hegde; Matthew W Vetting; Lesley A Mitchenall; Anthony Maxwell; John S Blanchard
Journal: Antimicrob Agents Chemother Date: 2010-10-11 Impact factor: 5.191

3. Cold shock induces qnrA expression in Shewanella algae.

Authors: Hong Bin Kim; Chi Hye Park; Mariah Gavin; George A Jacoby; David C Hooper
Journal: Antimicrob Agents Chemother Date: 2010-11-15 Impact factor: 5.191

4. Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein.

Authors: Matthew W Vetting; Subray S Hegde; Keith Z Hazleton; John S Blanchard
Journal: Protein Sci Date: 2007-04 Impact factor: 6.725

5. Thiol-based redox modulation of a cyanobacterial eukaryotic-type serine/threonine kinase required for oxidative stress tolerance.

Authors: Alejandro Mata-Cabana; Mario García-Domínguez; Francisco J Florencio; Marika Lindahl
Journal: Antioxid Redox Signal Date: 2012-06-04 Impact factor: 8.401

10. Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142.

Authors: Garry W Buchko; Shuisong Ni; Howard Robinson; Eric A Welsh; Himadri B Pakrasi; Michael A Kennedy
Journal: Protein Sci Date: 2006-11 Impact factor: 6.725