Literature DB >> 16377707

5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis.

Jacqueline A Upcroft1, Linda A Dunn, Janelle M Wright, Kamel Benakli, Peter Upcroft, Patrice Vanelle.   

Abstract

Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.

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Year:  2006        PMID： 16377707      PMCID： PMC1346785          DOI： 10.1128/AAC.50.1.344-347.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Functional derivatives of 5-benzo[1, 3]dioxol-5-yl-1-methyl-1H-imidazole-2-carbaldehyde and evaluation of leishmanicidal activity.

Authors:  P Vanelle; J Meuche; J Maldonado; M P Crozet; F Delmas; P Timon-David
Journal:  Eur J Med Chem       Date:  2000-01       Impact factor: 6.514

2.  Drug susceptibility testing of anaerobic protozoa.

Authors:  J A Upcroft; P Upcroft
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

Review 3.  Methods for cultivation of luminal parasitic protists of clinical importance.

Authors:  C Graham Clark; Louis S Diamond
Journal:  Clin Microbiol Rev       Date:  2002-07       Impact factor: 26.132

4.  In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.

Authors:  Andrea L Crowell; Kolby A Sanders-Lewis; W Evan Secor
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

5.  Induction of metronidazole and furazolidone resistance in Giardia.

Authors:  S M Townson; H Laqua; P Upcroft; P F Boreham; J A Upcroft
Journal:  Trans R Soc Trop Med Hyg       Date:  1992 Sep-Oct       Impact factor: 2.184

Review 6.  Drug targets and mechanisms of resistance in the anaerobic protozoa.

Authors:  P Upcroft; J A Upcroft
Journal:  Clin Microbiol Rev       Date:  2001-01       Impact factor: 26.132

7.  Trichomonas vaginalis-induced epithelial monolayer disruption and human immunodeficiency virus type 1 (HIV-1) replication: implications for the sexual transmission of HIV-1.

Authors:  Patricia C Guenthner; W Evan Secor; Charlene S Dezzutti
Journal:  Infect Immun       Date:  2005-07       Impact factor: 3.441

Review 8.  Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis.

Authors:  Rebecca L Dunne; Linda A Dunn; Peter Upcroft; Peter J O'Donoghue; Jacqueline A Upcroft
Journal:  Cell Res       Date:  2003-08       Impact factor: 25.617

Review 9.  Trichomonas vaginalis, HIV, and African-Americans.

Authors:  F Sorvillo; L Smith; P Kerndt; L Ash
Journal:  Emerg Infect Dis       Date:  2001 Nov-Dec       Impact factor: 6.883

Review 10.  Efficacy of antigiardial drugs.

Authors:  Janelle M Wright; Linda A Dunn; Peter Upcroft; Jacqueline A Upcroft
Journal:  Expert Opin Drug Saf       Date:  2003-11       Impact factor: 4.250
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  36 in total

1.  A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro.

Authors:  Linda A Dunn; Anita G Burgess; Kenia G Krauer; Lars Eckmann; Patrice Vanelle; Maxime D Crozet; Frances D Gillin; Peter Upcroft; Jacqueline A Upcroft
Journal:  Int J Antimicrob Agents       Date:  2010-04-24       Impact factor: 5.283

2.  Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine.

Authors:  Janelle M Wright; Linda A Dunn; Zygmunt Kazimierczuk; Anita G Burgess; Kenia G Krauer; Peter Upcroft; Jacqueline A Upcroft
Journal:  Parasitol Res       Date:  2010-06-09       Impact factor: 2.289

3.  A rapid, high-throughput viability assay for Blastocystis spp. reveals metronidazole resistance and extensive subtype-dependent variations in drug susceptibilities.

Authors:  Haris Mirza; Joshua D W Teo; Jacqui Upcroft; Kevin S W Tan
Journal:  Antimicrob Agents Chemother       Date:  2010-11-22       Impact factor: 5.191

4.  Development of metronidazole-resistant lines of Blastocystis sp.

Authors:  L A Dunn; K S W Tan; P Vanelle; T Juspin; M D Crozet; T Terme; P Upcroft; J A Upcroft
Journal:  Parasitol Res       Date:  2012-02-24       Impact factor: 2.289

5.  First report of anti-Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi-arid region, Caatinga.

Authors:  Amanda Piccoli Frasson; Odelta dos Santos; Mariana Duarte; Danielle da Silva Trentin; Raquel Brandt Giordani; Alexandre Gomes da Silva; Márcia Vanusa da Silva; Tiana Tasca; Alexandre José Macedo
Journal:  Parasitol Res       Date:  2011-12-29       Impact factor: 2.289

6.  In Vitro Study of the Susceptibility of Clinical Isolates of Trichomonas vaginalis to Metronidazole and Secnidazole.

Authors:  Arindam P Ghosh; Cheri Aycock; Jane R Schwebke
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

7.  Chlorinated metronidazole as a promising alternative for treating trichomoniasis.

Authors:  M O Chacon; T H S Fonseca; S B V Oliveira; M A Alacoque; L L Franco; C A Tagliati; G D Cassali; G P Campos-Mota; R J Alves; L S A Capettini; Maria Aparecida Gomes
Journal:  Parasitol Res       Date:  2018-03-03       Impact factor: 2.289

8.  Are the fatty acids responsible for the higher effect of oil and alcoholic extract of Nigella sativa over its aqueous extract on Trichomonas vaginalis trophozoites?

Authors:  Mona Abd El-Fattah Ahmad Mahmoud; Heba AbdelKader Aminou; Hanan Ahmed Hashem
Journal:  J Parasit Dis       Date:  2014-06-03

9.  Overexpression of the rhamnose catabolism regulatory protein, RhaR: a novel mechanism for metronidazole resistance in Bacteroides thetaiotaomicron.

Authors:  Ekta H Patel; Lynthia V Paul; Ana I Casanueva; Sheila Patrick; Valerie R Abratt
Journal:  J Antimicrob Chemother       Date:  2009-06-13       Impact factor: 5.790

10.  The old and new therapeutic approaches to the treatment of giardiasis: where are we?

Authors:  Haendel G N O Busatti; Joseph F G Santos; Maria A Gomes
Journal:  Biologics       Date:  2009-07-13
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