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Literature DB >> 1630488

Molecular replication.

Abstract

Simple replicating molecules are likely to have played a critical role in the origin of life. Recent experiments show that non-enzymatic replication is conceivable in a wide range of synthetic chemical systems. The challenge now facing these studies is how to develop information-coding systems from simple prebiotic precursors.

Keywords: NASA Discipline Exobiology; Non-NASA Center

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Substances：

Year: 1992 PMID： 1630488 DOI： 10.1038/358203a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

78 in total

1. The evolution of replicators.

Authors: E Szathmáry
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2000-11-29 Impact factor: 6.237

2. The fidelity of template-directed oligonucleotide ligation and the inevitability of polymerase function.

Authors: K D James; A D Ellington
Journal: Orig Life Evol Biosph Date: 1999-08 Impact factor: 1.950

3. Compositional genomes: prebiotic information transfer in mutually catalytic noncovalent assemblies.

Authors: D Segré; D Ben-Eli; D Lancet
Journal: Proc Natl Acad Sci U S A Date: 2000-04-11 Impact factor: 11.205

4. Taming combinatorial explosion.

Authors: P Schuster
Journal: Proc Natl Acad Sci U S A Date: 2000-07-05 Impact factor: 11.205

5. Emergence of template-and-sequence-directed (TSD) syntheses: I. A bio-geochemical model.

Authors: N Lahav; S Nir
Journal: Orig Life Evol Biosph Date: 1997-08 Impact factor: 1.950

6. Adsorption of 5'-AMP and catalytic synthesis of 5'-ADP onto phosphate surfaces: correlation to solid matrix structures.

Authors: A C Tessis; H Salim De Amorim; M Farina; F DeSouza-Barros; A Vieyra
Journal: Orig Life Evol Biosph Date: 1995-08 Impact factor: 1.950

Molecular replication.

1. The evolution of replicators.

2. The fidelity of template-directed oligonucleotide ligation and the inevitability of polymerase function.

3. Compositional genomes: prebiotic information transfer in mutually catalytic noncovalent assemblies.

4. Taming combinatorial explosion.

5. Emergence of template-and-sequence-directed (TSD) syntheses: I. A bio-geochemical model.

6. Adsorption of 5'-AMP and catalytic synthesis of 5'-ADP onto phosphate surfaces: correlation to solid matrix structures.

7. Chemical amplification with encapsulated reagents.

8. Importance of compartment formation for a self-encoding system.

Review 9. Spatial dynamics and the evolution of enzyme production.

10. Formamide as the main building block in the origin of nucleic acids.