Literature DB >> 11880614

Chemical amplification with encapsulated reagents.

Jian Chen1, Steffi Körner, Stephen L Craig, Shirley Lin, Dmitry M Rudkevich, Julius Rebek.   

Abstract

Autocatalysis and chemical amplification are characteristic properties of living systems, and they give rise to behaviors such as increased sensitivity, responsiveness, and self-replication. Here we report a synthetic system in which a unique form of compartmentalization leads to nonlinear, autocatalytic behavior. The compartment is a reversibly formed capsule in which a reagent is sequestered. Reaction products displace the reagent from the capsule into solution and the reaction rate is accelerated. The resulting self-regulation is sensitive to the highly selective molecular recognition properties of the capsule.

Year:  2002        PMID： 11880614      PMCID： PMC122392          DOI： 10.1073/pnas.052706499

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  6 in total

1.  Stabilization of a Reactive Cationic Species by Supramolecular Encapsulation Coordination Number Incommensurate Cluster Formation, Part 15. This research was supported by NSF grant CHE-9709621. We gratefully acknowledge Prof. Julie A. Leary and Dr. Ulla Andersen for their assistance with mass spectrometry. We also thank the Miller Foundation for a postdoctoral fellowship to M.Z. and the NIH for a postdoctoral fellowship to J.L.B. Part 14: J. Xide, K. N. Raymond, Angew. Chem. 2000, 112, 2857-2859; Angew. Chem. Int. Ed. 2000, 39, 2745-2747.

Authors: 
Journal:  Angew Chem Int Ed Engl       Date:  2000-11-17       Impact factor: 15.336

2.  Self-Assembling Capsules.

Authors:  M. Morgan Conn; Julius Rebek
Journal:  Chem Rev       Date:  1997-08-05       Impact factor: 60.622

Review 3.  Molecular replication.

Authors:  L E Orgel
Journal:  Nature       Date:  1992-07-16       Impact factor: 49.962

4.  A self-replicating peptide.

Authors:  D H Lee; J R Granja; J A Martinez; K Severin; M R Ghadiri
Journal:  Nature       Date:  1996-08-08       Impact factor: 49.962

5.  Molecular Recognition within a Self-Assembled Cylindrical Host.

Authors:  T Heinz; D M Rudkevich; J Rebek
Journal:  Angew Chem Int Ed Engl       Date:  1999       Impact factor: 15.336

6.  A self-assembled cylindrical capsule: new supramolecular phenomena through encapsulation.

Authors:  S K Körner; F C Tucci; D M Rudkevich; T Heinz; J Rebek
Journal:  Chemistry       Date:  2000-01       Impact factor: 5.236
  6 in total
  5 in total

1.  Experimental and computational probes of the space in a self-assembled capsule.

Authors:  Dariush Ajami; Tetsuo Iwasawa; Julius Rebek
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-02       Impact factor: 11.205

2.  A novel metal-organic framework of Ba-hemin with enhanced cascade activity for sensitive glucose detection.

Authors:  Jintao Yi; Xianqin Han; Fengying Gao; Le Cai; Ying Chen; Xiulong Deng; Xun Li; Jun Xue; Hui Zhou
Journal:  RSC Adv       Date:  2022-07-15       Impact factor: 4.036

3.  Self-organization by selection: generation of a metallosupramolecular grid architecture by selection of components in a dynamic library of ligands.

Authors:  Jonathan R Nitschke; Jean-Marie Lehn
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-29       Impact factor: 11.205

4.  PCR-like cascade reactions in the context of an allosteric enzyme mimic.

Authors:  Hyo Jae Yoon; Chad A Mirkin
Journal:  J Am Chem Soc       Date:  2008-08-06       Impact factor: 15.419

5.  Reaction of an Introverted Carboxylic Acid with Carbodiimide.

Authors:  Tetsuo Iwasawa; Paul Wash; Christoph Gibson; Julius Rebek
Journal:  Tetrahedron       Date:  2007-07-09       Impact factor: 2.457
  5 in total

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