Literature DB >> 16304182

Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme.

Nahoko Uchiyama1, Zakayi Kabututu, Bruno K Kubata, Fumiyuki Kiuchi, Michiho Ito, Junko Nakajima-Shimada, Takashi Aoki, Kei Ohkubo, Shunichi Fukuzumi, Samuel K Martin, Gisho Honda, Yoshihiro Urade.   

Abstract

A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.

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Year:  2005        PMID： 16304182      PMCID： PMC1315950          DOI： 10.1128/AAC.49.12.5123-5126.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

Review 1.  Specific chemotherapy of Chagas disease: controversies and advances.

Authors:  Julio A Urbina; Roberto Docampo
Journal:  Trends Parasitol       Date:  2003-11

2.  Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives.

Authors:  Juan Diego Maya; Soledad Bollo; Luis J Nuñez-Vergara; Juan A Squella; Yolanda Repetto; Antonio Morello; Jacques Périé; Gérard Chauvière
Journal:  Biochem Pharmacol       Date:  2003-03-15       Impact factor: 5.858

3.  New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium.

Authors:  N Murakami; H M Mostaqul; S Tamura; S Itagaki; T Horii; M Kobayashi
Journal:  Bioorg Med Chem Lett       Date:  2001-09-17       Impact factor: 2.823

4.  Novel cassane and cleistanthane diterpenes from Myrospermum frutescens: absolute stereochemistry of the cassane diterpene series.

Authors:  Daniel Torres-Mendoza; Luis David Ureña González; Eduardo Ortega-Barría; Phyllis D Coley; Thomas A Kursar; Todd L Capson; Kerry McPhail; Luis Cubilla-Rios
Journal:  J Nat Prod       Date:  2004-10       Impact factor: 4.050

5.  Five new cassane diterpenes from Myrospermum frutescens with activity against Trypanosoma cruzi.

Authors:  Daniel Torres Mendoza; Luis D Ureña González; Eduardo Ortega-Barría; Todd L Capson; Luis Cubilla Rios
Journal:  J Nat Prod       Date:  2003-07       Impact factor: 4.050

6.  Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi.

Authors:  Jorge E Araya; Iván Neira; Solange da Silva; Renato A Mortara; Patricio Manque; Esteban Cordero; Hernán Sagua; Alberto Loyola; Jorge Bórquez; Glauco Morales; Jorge González
Journal:  Mem Inst Oswaldo Cruz       Date:  2003-07-18       Impact factor: 2.743

7.  Microarray profiling of gene expression during trypomastigote to amastigote transition in Trypanosoma cruzi.

Authors:  Todd A Minning; Jacqueline Bua; Gabriela A Garcia; R A McGraw; Rick L Tarleton
Journal:  Mol Biochem Parasitol       Date:  2003-09       Impact factor: 1.759

8.  Enzymatic reduction studies of nitroheterocycles.

Authors:  C Viodé; N Bettache; N Cenas; R L Krauth-Siegel; G Chauvière; N Bakalara; J Périé
Journal:  Biochem Pharmacol       Date:  1999-03-01       Impact factor: 5.858

9.  New icetexane and 20 norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi.

Authors:  Nahoko Uchiyama; Fumiyuki Kiuchi; Michiho Ito; Gisho Honda; Yoshio Takeda; Olimjon K Khodzhimatov; Ozodbek A Ashurmetov
Journal:  J Nat Prod       Date:  2003-01       Impact factor: 4.050

10.  A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi.

Authors:  Bruno Kilunga Kubata; Zakayi Kabututu; Tomoyoshi Nozaki; Craig J Munday; Shunichi Fukuzumi; Kei Ohkubo; Michael Lazarus; Toshihiko Maruyama; Samuel K Martin; Michael Duszenko; Yoshihiro Urade
Journal:  J Exp Med       Date:  2002-11-04       Impact factor: 14.307
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  9 in total

1.  Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi.

Authors:  Monica C O Campos; Kelly Salomão; Denise B Castro-Pinto; Leonor L Leon; Helene S Barbosa; Maria Aparecida M Maciel; Solange L de Castro
Journal:  Parasitol Res       Date:  2010-08-03       Impact factor: 2.289

2.  Nitroreductase Increases Menadione-Mediated Oxidative Stress in Aspergillus nidulans.

Authors:  Yao Zhou; Hangya Lv; Haoxiang Li; Jingyi Li; Yunfeng Yan; Feiyun Liu; Wenliang Hao; Zhemin Zhou; Ping Wang; Shengmin Zhou
Journal:  Appl Environ Microbiol       Date:  2021-10-06       Impact factor: 5.005

3.  Synthetic studies on the icetexones: enantioselective formal syntheses of icetexone and epi-icetexone.

Authors:  Felipe de Jesus Cortez; David Lapointe; Amy M Hamlin; Eric M Simmons; Richmond Sarpong
Journal:  Tetrahedron       Date:  2013-07-08       Impact factor: 2.457

Review 4.  Current and developing therapeutic agents in the treatment of Chagas disease.

Authors:  Werner Apt
Journal:  Drug Des Devel Ther       Date:  2010-09-24       Impact factor: 4.162

5.  Old Yellow Enzyme from Trypanosoma cruzi Exhibits In Vivo Prostaglandin F2α Synthase Activity and Has a Key Role in Parasite Infection and Drug Susceptibility.

Authors:  Florencia Díaz-Viraqué; María Laura Chiribao; Andrea Trochine; Fabiola González-Herrera; Christian Castillo; Ana Liempi; Ulrike Kemmerling; Juan Diego Maya; Carlos Robello
Journal:  Front Immunol       Date:  2018-03-07       Impact factor: 7.561

6.  Synthesis, Structure-Activity Relationships, and Parasitological Profiling of Brussonol Derivatives as New Plasmodium falciparum Inhibitors.

Authors:  Camila S Barbosa; Anees Ahmad; Sarah El Chamy Maluf; Igor M R Moura; Guilherme E Souza; Giovanna A H Guerra; Roberto R Moraes Barros; Marcos L Gazarini; Anna C C Aguiar; Antonio C B Burtoloso; Rafael V C Guido
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-30

7.  Anti-oxidative trypanocidal drugs, myth or reality.

Authors:  Soodabeh Saeidnia
Journal:  Daru       Date:  2013-03-12       Impact factor: 3.117

8.  (1'S,6'S,8'S,9'R)-9'-Bromo-12'-oxa-spiro-[1,3-dioxolane-2,4'-tricyclo-[6.3.1.0(1,6)]dodeca-ne].

Authors:  Goverdhan Mehta; Tabrez Babu Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-07-10

9.  Effects of astaxanthin in mice acutely infected with Trypanosoma cruzi.

Authors:  José María Eloy Contreras-Ortiz; Alberto Barbabosa-Pliego; Rigoberto Oros-Pantoja; José Esteban Aparicio-Burgos; José Antonio Zepeda-Escobar; Wael Hegazy Hassan-Moustafa; Laucel Ochoa-García; María Uxúa Alonso-Fresan; Esvieta Tenorio Borroto; Juan Carlos Vázquez-Chagoyán
Journal:  Parasite       Date:  2017-05-31       Impact factor: 3.000
  9 in total

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