Literature DB >> 11549443

New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium.

N Murakami1, H M Mostaqul, S Tamura, S Itagaki, T Horii, M Kobayashi.   

Abstract

Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.

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Year:  2001        PMID： 11549443     DOI： 10.1016/s0960-894x(01)00467-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

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Journal:  Molecules       Date:  2022-05-26       Impact factor: 4.927

3.  Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides.

Authors:  Yasinjan Hashim; Kazufumi Toume; Shusaku Mizukami; Yue-Wei Ge; Mayumi Taniguchi; Awet Alem Teklemichael; Nguyen Tien Huy; Joseph M Bodi; Kenji Hirayama; Katsuko Komatsu
Journal:  J Nat Med       Date:  2021-06-29       Impact factor: 2.343

4.  In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca.

Authors:  Pranorm Khaomek; Chikara Ichino; Aki Ishiyama; Hitomi Sekiguchi; Miyuki Namatame; Nijsiri Ruangrungsi; Ekarin Saifah; Hiroaki Kiyohara; Kazuhiko Otoguro; Satoshi Omura; Haruki Yamada
Journal:  J Nat Med       Date:  2008-01-30       Impact factor: 2.343
  4 in total

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