Literature DB >> 12542361

New icetexane and 20 norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi.

Nahoko Uchiyama1, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshio Takeda, Olimjon K Khodzhimatov, Ozodbek A Ashurmetov.   

Abstract

Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 micro M.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12542361     DOI： 10.1021/np020308z

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme.

Authors:  Nahoko Uchiyama; Zakayi Kabututu; Bruno K Kubata; Fumiyuki Kiuchi; Michiho Ito; Junko Nakajima-Shimada; Takashi Aoki; Kei Ohkubo; Shunichi Fukuzumi; Samuel K Martin; Gisho Honda; Yoshihiro Urade
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

2.  Catalytic Enantioselective Intermolecular [5 + 2] Dipolar Cycloadditions of a 3-Hydroxy-4-pyrone-Derived Oxidopyrylium Ylide.

Authors:  Katherine N Fuhr; Danielle R Hirsch; Ryan P Murelli; Stacey E Brenner-Moyer
Journal:  Org Lett       Date:  2017-11-17       Impact factor: 6.005

3.  Dual catalysis in enantioselective oxidopyrylium-based [5 + 2] cycloadditions.

Authors:  Noah Z Burns; Michael R Witten; Eric N Jacobsen
Journal:  J Am Chem Soc       Date:  2011-08-25       Impact factor: 15.419

4.  Dirhodium(II)-Catalyzed Annulation of Enoldiazoacetamides with α-Diazoketones: An Efficient and Highly Selective Approach to Fused and Bridged Ring Systems.

Authors:  Qing-Qing Cheng; Julietta Yedoyan; Hadi Arman; Michael P Doyle
Journal:  Angew Chem Int Ed Engl       Date:  2016-03-23       Impact factor: 15.336

5.  A Rh(II)-catalyzed cycloaddition approach towards the synthesis of komaroviquinone.

Authors:  Albert Padwa; Majid J Chughtai; Jutatip Boonsombat; Paitoon Rashatasakhon
Journal:  Tetrahedron       Date:  2008-05-19       Impact factor: 2.457

6.  Cytotoxic Terpenoids from the Roots of Dracocephalum taliense.

Authors:  Yanyan Deng; Juan Hua; Wenjia Wang; Zhonglang Zhan; Anqi Wang; Shihong Luo
Journal:  Molecules       Date:  2017-12-27       Impact factor: 4.411

7.  Synthesis, Structure-Activity Relationships, and Parasitological Profiling of Brussonol Derivatives as New Plasmodium falciparum Inhibitors.

Authors:  Camila S Barbosa; Anees Ahmad; Sarah El Chamy Maluf; Igor M R Moura; Guilherme E Souza; Giovanna A H Guerra; Roberto R Moraes Barros; Marcos L Gazarini; Anna C C Aguiar; Antonio C B Burtoloso; Rafael V C Guido
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-30
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.