Literature DB >> 1629172

A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens.

O Hara1, C R Hutchinson.   

Abstract

The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene.

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Year:  1992        PMID： 1629172      PMCID： PMC206334          DOI： 10.1128/jb.174.15.5141-5144.1992

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  13 in total

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Authors:  C R Hutchinson
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Authors:  D A Hopwood; M J Bibb; K F Chater; T Kieser
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Authors:  M Salminen; K Lundström; C Tilgmann; R Savolainen; N Kalkkinen; I Ulmanen
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4.  A comprehensive set of sequence analysis programs for the VAX.

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5.  Molecular characterization of the O-acetyl transferase gene of converting bacteriophage SF6 that adds group antigen 6 to Shigella flexneri.

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6.  Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases.

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Authors:  M J Bibb; S N Cohen
Journal:  Mol Gen Genet       Date:  1982

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Authors:  D A Hopwood; T Kieser; H M Wright; M J Bibb
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Authors:  D Schmitt; A E Pakusch; U Matern
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10.  Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.

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Journal:  J Biol Chem       Date:  1989-11-25       Impact factor: 5.157
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  20 in total

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Journal:  J Bacteriol       Date:  1997-05       Impact factor: 3.490

2.  Duplication of the pepF gene and shuffling of DNA fragments on the lactose plasmid of Lactococcus lactis.

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Review 3.  Recombinant organisms for production of industrial products.

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5.  Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic.

Authors:  A Arisawa; N Kawamura; K Takeda; H Tsunekawa; K Okamura; R Okamoto
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8.  Molecular characterization of the oafA locus responsible for acetylation of Salmonella typhimurium O-antigen: oafA is a member of a family of integral membrane trans-acylases.

Authors:  J M Slauch; A A Lee; M J Mahan; J J Mekalanos
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9.  An erythromycin analog produced by reprogramming of polyketide synthesis.

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10.  Functional and structural characterization of a cation-dependent O-methyltransferase from the cyanobacterium Synechocystis sp. strain PCC 6803.

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