Literature DB >> 16169235

Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa.

Anna Aiello1, Monica D'Esposito, Ernesto Fattorusso, Marialuisa Menna, Werner E G Müller, Sanja Perović-Ottstadt, Heinz C Schröder.   

Abstract

The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5-18, four novel alkaloids of this class, compounds 1-4, have been isolated, and their structures established through spectroscopic methods. Compounds 1-4 were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.

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Year:  2005        PMID： 16169235     DOI： 10.1016/j.bmc.2005.07.057

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  14 in total

1.  Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.

Authors:  Fan Yang; Mark T Hamann; Yike Zou; Ming-Yu Zhang; Xiao-Bin Gong; Jian-Ru Xiao; Wan-Sheng Chen; Hou-Wen Lin
Journal:  J Nat Prod       Date:  2012-02-23       Impact factor: 4.050

2.  Bromopyrrole alkaloids as lead compounds against protozoan parasites.

Authors:  Fernando Scala; Ernesto Fattorusso; Marialuisa Menna; Orazio Taglialatela-Scafati; Michelle Tierney; Marcel Kaiser; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2010-07-14       Impact factor: 5.118

Review 3.  Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Biochim Biophys Acta       Date:  2009-03-19

Review 4.  Marine Pyrrole Alkaloids.

Authors:  Kevin Seipp; Leander Geske; Till Opatz
Journal:  Mar Drugs       Date:  2021-09-10       Impact factor: 5.118

5.  Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles.

Authors:  Rosario Astrid Vargas Cárdenas; Blanca Olinda Quintanilla Leal; Ashwini Reddy; Debasish Bandyopadhyay; Bimal K Banik
Journal:  Org Med Chem Lett       Date:  2012-06-22

6.  Cytotoxic Activity of Crude Extracts as well as of Pure Components from Jatropha Species, Plants Used Extensively in African Traditional Medicine.

Authors:  Olapeju O Aiyelaagbe; Amao A Hamid; Ernesto Fattorusso; Orazio Taglialatela-Scafati; Heinz C Schröder; Werner E G Müller
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-15       Impact factor: 2.629

Review 7.  Trypanocidal activity of marine natural products.

Authors:  Amy J Jones; Tanja Grkovic; Melissa L Sykes; Vicky M Avery
Journal:  Mar Drugs       Date:  2013-10-22       Impact factor: 5.118

8.  Bioactive marine drugs and marine biomaterials for brain diseases.

Authors:  Clara Grosso; Patrícia Valentão; Federico Ferreres; Paula B Andrade
Journal:  Mar Drugs       Date:  2014-05-02       Impact factor: 5.118

9.  Further investigation of the Mediterranean sponge Axinella polypoides: isolation of a new cyclonucleoside and a new betaine.

Authors:  Marialuisa Menna; Anna Aiello; Filomena D'Aniello; Ernesto Fattorusso; Concetta Imperatore; Paolo Luciano; Rocco Vitalone
Journal:  Mar Drugs       Date:  2012-11-09       Impact factor: 5.118

10.  The marine sponge Agelas citrina as a source of the new pyrrole-imidazole alkaloids citrinamines A-D and N-methylagelongine.

Authors:  Christine Cychon; Ellen Lichte; Matthias Köck
Journal:  Beilstein J Org Chem       Date:  2015-10-29       Impact factor: 2.883
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