Literature DB >> 16125394

Cytotoxic diterpenoids from two lianas from the Suriname rainforest.

Eba Adou1, Russell B Williams, Jennifer K Schilling, Stan Malone, Jan Meyer, Jan H Wisse, Djon Frederik, Delon Koese, Marga C M Werkhoven, Carl E Snipes, Todd L Werk, David G I Kingston.   

Abstract

Bioassay-guided fractionation of the MeOH and EtOAc fractions of extracts of two lianas collected in Suriname has led to the isolation of five new diterpenoids, humirianthone 1, 1-hydroxy-humirianthone 2, 15R-humirianthol 3, patagonol 4, and patagonal 5, and the five known diterpenoids, humirianthol 7, annonalide 8, acrenol 9, icacinol 10, and the oxidized annonalide 11. All 10 diterpenoids showed cytotoxic activity against the A2780 human ovarian cancer cell line, and compounds 1, 3, 8, and 9 also showed activity against phytopathogenic fungi.

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Year:  2005        PMID： 16125394     DOI： 10.1016/j.bmc.2005.07.026

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  11 in total

1.  17-Norpimaranes and (9βH)-17-Norpimaranes from the Tuber of Icacina trichantha.

Authors:  Ming Zhao; Michael Monday Onakpa; Wei-Lun Chen; Bernard D Santarsiero; Steven M Swanson; Joanna E Burdette; Isaac Uzoma Asuzu; Chun-Tao Che
Journal:  J Nat Prod       Date:  2015-03-17       Impact factor: 4.050

2.  Activity of Icacinol from Icacina trichantha on Seedling Growth of Oryza sativa and Arabidopsis thaliana.

Authors:  Ming Zhao; Brian Guo; Michael M Onakpa; Tiffany Wong; Kyo Wakasa; Chun-Tao Che; Katherine Warpeha
Journal:  J Nat Prod       Date:  2017-12-11       Impact factor: 4.050

3.  19-nor-pimaranes from Icacina trichantha.

Authors:  Brian Guo; Ming Zhao; Zhenlong Wu; Monday M Onakpa; Joanna E Burdette; Chun-Tao Che
Journal:  Fitoterapia       Date:  2020-05-11       Impact factor: 2.882

4.  (9βH)- and 17-Nor-Pimaranes from Icacina oliviformis.

Authors:  Meng Sun; Brian Guo; Mingming Xu; Ming Zhao; Monday M Onakpa; Zhenlong Wu; Joanna E Burdette; Chun-Tao Che
Journal:  J Nat Prod       Date:  2021-03-26       Impact factor: 4.050

5.  Scrodentoids H and I, a Pair of Natural Epimerides from Scrophularia dentata, Inhibit Inflammation through JNK-STAT3 Axis in THP-1 Cells.

Authors:  Gaohui Mao; Liqin Sun; Jinwen Xu; Yiming Li; Ciren Dunzhu; Liuqiang Zhang; Fei Qian
Journal:  Evid Based Complement Alternat Med       Date:  2020-07-27       Impact factor: 2.629

Review 6.  Icacina trichantha, A Tropical Medicinal Plant.

Authors:  Chun-Tao Che; Ming Zhao; Brian Guo; Michael M Onakpa
Journal:  Nat Prod Commun       Date:  2016-07       Impact factor: 0.986

7.  Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest.

Authors:  Shugeng Cao; Mohamed M Radwan; Andrew Norris; James S Miller; Fidy Ratovoson; Andrianjafy Mamisoa; Rabodo Andriantsiferana; Vincent E Rasamison; Stephan Rakotonandrasana; David G I Kingston
Journal:  J Nat Prod       Date:  2006-02       Impact factor: 4.050

8.  Cytotoxic diterpenes from Cassipourea madagascariensis from the Madagascar rainforest.

Authors:  V S Prakash Chaturvedula; Andrew Norris; James S Miller; Fidisoa Ratovoson; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2006-02       Impact factor: 4.050

9.  Ipomoeassin F, a new cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest.

Authors:  Shugeng Cao; Andrew Norris; Jan H Wisse; James S Miller; Randy Evans; David G I Kingston
Journal:  Nat Prod Res       Date:  2007-08       Impact factor: 2.861

10.  Biodiversity conservation and drug discovery: Can they be combined? The Suriname and Madagascar experiences.

Authors:  Shugeng Cao; David G I Kingston
Journal:  Pharm Biol       Date:  2009-08-01       Impact factor: 3.503
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