Literature DB >> 17680496

Ipomoeassin F, a new cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest.

Shugeng Cao1, Andrew Norris, Jan H Wisse, James S Miller, Randy Evans, David G I Kingston.   

Abstract

A new cytotoxic macrocyclic glycoresin, ipomoeassin F (6), has been isolated from the leaves of Ipomoea squamosa. The structure was elucidated by the interpretation of spectral data. Compound 6 was strongly active in the A2780 (human ovarian cancer cell line) assay with an IC(50) value of 0.036 microM.

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Year:  2007        PMID： 17680496      PMCID： PMC2776619          DOI： 10.1080/14786410600929576

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  2 in total

1.  Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of Ipomoea squamosa from the Suriname rainforest.

Authors:  Shugeng Cao; Rebecca C Guza; Jan H Wisse; James S Miller; Randy Evans; David G I Kingston
Journal:  J Nat Prod       Date:  2005-04       Impact factor: 4.050

2.  Cytotoxic diterpenoids from two lianas from the Suriname rainforest.

Authors:  Eba Adou; Russell B Williams; Jennifer K Schilling; Stan Malone; Jan Meyer; Jan H Wisse; Djon Frederik; Delon Koese; Marga C M Werkhoven; Carl E Snipes; Todd L Werk; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2005-11-01       Impact factor: 3.641
  2 in total
  13 in total

1.  Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer.

Authors:  Guanghui Zong; Eric Barber; Hazim Aljewari; Jianhong Zhou; Zhijian Hu; Yuchun Du; Wei Q Shi
Journal:  J Org Chem       Date:  2015-09-04       Impact factor: 4.354

2.  Antiproliferative cardenolides from Pentopetia androsaemifolia Decne. from the Madagascar rain forest.

Authors:  Eba Adou; James S Miller; Fidisoa Ratovoson; Chris Birkinshaw; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  Indian J Exp Biol       Date:  2010-03       Impact factor: 0.818

3.  New insights into structure-activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analogues.

Authors:  Guanghui Zong; Xianwei Sun; Rima Bhakta; Lucas Whisenhunt; Zhijian Hu; Feng Wang; Wei Q Shi
Journal:  Eur J Med Chem       Date:  2017-12-12       Impact factor: 6.514

4.  Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin F.

Authors:  Guanghui Zong; Melissa Hirsch; Collin Mondrik; Zhijian Hu; Wei Q Shi
Journal:  Bioorg Med Chem Lett       Date:  2017-04-21       Impact factor: 2.823

5.  Synergistic Contribution of Tiglate and Cinnamate to Cytotoxicity of Ipomoeassin F.

Authors:  Guanghui Zong; Lucas Whisenhunt; Zhijian Hu; Wei Q Shi
Journal:  J Org Chem       Date:  2017-04-17       Impact factor: 4.354

Review 6.  Natural products as modulators of eukaryotic protein secretion.

Authors:  Hendrik Luesch; Ville O Paavilainen
Journal:  Nat Prod Rep       Date:  2020-02-18       Impact factor: 13.423

7.  Revealing the Pharmacophore of Ipomoeassin F through Molecular Editing.

Authors:  Guanghui Zong; Hazim Aljewari; Zhijian Hu; Wei Q Shi
Journal:  Org Lett       Date:  2016-03-21       Impact factor: 6.005

8.  Biodiversity conservation and drug discovery: Can they be combined? The Suriname and Madagascar experiences.

Authors:  Shugeng Cao; David G I Kingston
Journal:  Pharm Biol       Date:  2009-08-01       Impact factor: 3.503

9.  Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.

Authors:  Guanghui Zong; Zhijian Hu; Sarah O'Keefe; Dale Tranter; Michael J Iannotti; Ludivine Baron; Belinda Hall; Katherine Corfield; Anja O Paatero; Mark J Henderson; Peristera Roboti; Jianhong Zhou; Xianwei Sun; Mugunthan Govindarajan; Jason M Rohde; Nicolas Blanchard; Rachel Simmonds; James Inglese; Yuchun Du; Caroline Demangel; Stephen High; Ville O Paavilainen; Wei Q Shi
Journal:  J Am Chem Soc       Date:  2019-05-15       Impact factor: 15.419

10.  Structure of the Inhibited State of the Sec Translocon.

Authors:  Samuel F Gérard; Belinda S Hall; Afroditi M Zaki; Katherine A Corfield; Peter U Mayerhofer; Catia Costa; Daniel K Whelligan; Philip C Biggin; Rachel E Simmonds; Matthew K Higgins
Journal:  Mol Cell       Date:  2020-07-09       Impact factor: 19.328
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