| Literature DB >> 16094312 |
Lyubomira Chakalova1, Emmanuel Debrand, Jennifer A Mitchell, Cameron S Osborne, Peter Fraser.
Abstract
As the relationship between nuclear structure and function begins to unfold, a picture is emerging of a dynamic landscape that is centred on the two main processes that execute the regulated use and propagation of the genome. Rather than being subservient enzymatic activities, the replication and transcriptional machineries provide potent forces that organize the genome in three-dimensional nuclear space. Their activities provide opportunities for epigenetic changes that are required for differentiation and development. In addition, they impose physical constraints on the genome that might help to shape its evolution.Entities:
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Year: 2005 PMID： 16094312 DOI： 10.1038/nrg1673
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242