Literature DB >> 16084401

The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis.

Michael S Caplan1, Dyan Simon, Tamas Jilling.   

Abstract

The pathogenesis of neonatal necrotizing enterocolitis remains poorly understood. Recent evidence suggests that PAF (platelet activating factor) and human toll-like receptors (TLRs) contribute to the pro-inflammatory response that is characteristic of NEC pathology. Understanding the regulation of these molecular interactions may provide new approaches for prevention or treatment of this dreaded condition.

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Year:  2005        PMID： 16084401     DOI： 10.1053/j.sempedsurg.2005.05.002

Source DB:  PubMed          Journal:  Semin Pediatr Surg        ISSN： 1055-8586            Impact factor:   2.754


  50 in total

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Review 2.  Toward improving mucosal barrier defenses: rhG-CSF plus IgG antibody.

Authors:  Aryeh Simmonds; Edmund F LaGamma
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Journal:  Indian J Pediatr       Date:  2006-11       Impact factor: 1.967

4.  Hypoxic-ischemic enterocolitis: a proposal of a new terminology for early NEC or NEC-like disease in preterm infants, a single-center prospective observational study.

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5.  Necrotizing enterocolitis in the premature infant: neonatal nursing assessment, disease pathogenesis, and clinical presentation.

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6.  Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis.

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Review 7.  The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis.

Authors:  Kathryn J Rowland; Pamela M Choi; Brad W Warner
Journal:  Semin Pediatr Surg       Date:  2013-05       Impact factor: 2.754

Review 8.  The role of the intestinal microcirculation in necrotizing enterocolitis.

Authors:  Daniel J Watkins; Gail E Besner
Journal:  Semin Pediatr Surg       Date:  2013-05       Impact factor: 2.754

Review 9.  Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis.

Authors:  Akhil Maheshwari
Journal:  Clin Perinatol       Date:  2015-05-13       Impact factor: 3.430

10.  Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia.

Authors:  Simon Keely; Louise E Glover; Thomas Weissmueller; Christopher F MacManus; Sophie Fillon; Blair Fennimore; Sean P Colgan
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