OBJECTIVE: To determine association of anemia and red blood cell (RBC) transfusions with necrotizing enterocolitis (NEC) in preterm infants. STUDY DESIGN: A total of 111 preterm infants with NEC ≥ stage 2a were compared with 222 matched controls. In all, 28 clinical variables, including hematocrit (Hct) and RBC transfusions were recorded. Propensity scores and multivariate logistic regression models were created to examine effects on the risk of NEC. RESULT: Controlling for other factors, lower Hct was associated with increased odds of NEC (odds ratio (OR)=1.10, P=0.01). RBC transfusion has a temporal relationship with NEC onset. Transfusion within 24 h (OR=7.60, P=0.001) and 48 h (OR=5.55, P=0.001) has a higher odds of developing NEC but this association is not significant by 96 h (OR=2.13, P=0.07), post-transfusion. CONCLUSION: Anemia may increase the risk of developing NEC in preterm infants. RBC transfusions are temporally related to NEC. Prospective studies are needed to better evaluate the potential influence of transfusions on the development of NEC.
OBJECTIVE: To determine association of anemia and red blood cell (RBC) transfusions with necrotizing enterocolitis (NEC) in preterm infants. STUDY DESIGN: A total of 111 preterm infants with NEC ≥ stage 2a were compared with 222 matched controls. In all, 28 clinical variables, including hematocrit (Hct) and RBC transfusions were recorded. Propensity scores and multivariate logistic regression models were created to examine effects on the risk of NEC. RESULT: Controlling for other factors, lower Hct was associated with increased odds of NEC (odds ratio (OR)=1.10, P=0.01). RBC transfusion has a temporal relationship with NEC onset. Transfusion within 24 h (OR=7.60, P=0.001) and 48 h (OR=5.55, P=0.001) has a higher odds of developing NEC but this association is not significant by 96 h (OR=2.13, P=0.07), post-transfusion. CONCLUSION:Anemia may increase the risk of developing NEC in preterm infants. RBC transfusions are temporally related to NEC. Prospective studies are needed to better evaluate the potential influence of transfusions on the development of NEC.
Authors: J A Lemons; C R Bauer; W Oh; S B Korones; L A Papile; B J Stoll; J Verter; M Temprosa; L L Wright; R A Ehrenkranz; A A Fanaroff; A Stark; W Carlo; J E Tyson; E F Donovan; S Shankaran; D K Stevenson Journal: Pediatrics Date: 2001-01 Impact factor: 7.124
Authors: C S Peter; M Feuerhahn; B Bohnhorst; M Schlaud; S Ziesing; H von der Hardt; C F Poets Journal: Eur J Pediatr Date: 1999-01 Impact factor: 3.183
Authors: T T B Ho; M W Groer; A A Luciano; A Schwartz; M Ji; B S Miladinovic; A Maheshwari; T L Ashmeade Journal: J Perinatol Date: 2015-07-16 Impact factor: 2.521
Authors: Connie M Arthur; Demet Nalbant; Henry A Feldman; Bejan J Saeedi; Jason Matthews; Brian S Robinson; Nourine A Kamili; Ashley Bennett; Gretchen A Cress; Martha Sola-Visner; Rheinallt M Jones; M Bridget Zimmerman; Andrew S Neish; Ravi M Patel; Peggy Nopoulos; Michael K Georgieff; John D Roback; John A Widness; Cassandra D Josephson; Sean R Stowell Journal: Transfusion Date: 2019-03-21 Impact factor: 3.157
Authors: Terri Marin; James Moore; Niki Kosmetatos; John D Roback; Paul Weiss; Melinda Higgins; Linda McCauley; Ora L Strickland; Cassandra D Josephson Journal: Transfusion Date: 2013-03-11 Impact factor: 3.157