Literature DB >> 1605614

Utilization of pulse oximetry for the study of the inhibitory effects of antiviral agents on influenza virus in mice.

R W Sidwell1, J H Huffman, J Gilbert, B Moscon, G Pedersen, R Burger, R P Warren.   

Abstract

Pulmonary disease in mice induced by influenza virus was monitored by measurement of oxygen saturation (SaO2) in blood with a pulse oximeter. The SaO2 declined in inverse proportion to the viral inoculum. The known antiviral agent ribavirin inhibited the SaO2 decline, prevented death, lowered lung consolidation, and reduced the level of recoverable virus. Pulse oximetry is an effective means of monitoring murine influenzal disease and can be used in the study of potential antiviral drugs.

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Year:  1992        PMID： 1605614      PMCID： PMC188461          DOI： 10.1128/AAC.36.2.473

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  Studies on the pathogenesis of influenza virus pneumonia in mice.

Authors:  J F HERS; J MUDLER; N MASUREL; L vd KUIP; D A TYRRELL
Journal:  J Pathol Bacteriol       Date:  1962-01

2.  Effect of selenazofurin on influenza A and B virus infections of mice.

Authors:  R W Sidwell; J H Huffman; E W Call; H Alaghamandan; P D Cook; R K Robins
Journal:  Antiviral Res       Date:  1986-10       Impact factor: 5.970

3.  Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

Authors:  R W Sidwell; J H Huffman; G P Khare; L B Allen; J T Witkowski; R K Robins
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

4.  Ribavirin small-particle aerosol treatment of influenza.

Authors:  V Knight; H W McClung; S Z Wilson; B K Waters; J M Quarles; R W Cameron; S E Greggs; J M Zerwas; R B Couch
Journal:  Lancet       Date:  1981-10-31       Impact factor: 79.321

Review 5.  Pulse oximetry: a review of the theory, accuracy, and clinical applications.

Authors:  W A Bowes; B C Corke; J Hulka
Journal:  Obstet Gynecol       Date:  1989-09       Impact factor: 7.661
  5 in total
  15 in total

Review 1.  The contribution of animal models to the understanding of the host range and virulence of influenza A viruses.

Authors:  Christopher D O'Donnell; Kanta Subbarao
Journal:  Microbes Infect       Date:  2011-01-27       Impact factor: 2.700

2.  Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice.

Authors:  Robert W Sidwell; Dale L Barnard; Craig W Day; Donald F Smee; Kevin W Bailey; Min-Hui Wong; John D Morrey; Yousuke Furuta
Journal:  Antimicrob Agents Chemother       Date:  2006-12-28       Impact factor: 5.191

3.  Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.

Authors:  Michael P Malakhov; Laura M Aschenbrenner; Donald F Smee; Miles K Wandersee; Robert W Sidwell; Larisa V Gubareva; Vasiliy P Mishin; Frederick G Hayden; Do Hyong Kim; Alice Ing; Erin R Campbell; Mang Yu; Fang Fang
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

4.  In vivo anti-influenza virus activity of a zinc finger peptide.

Authors:  A K Judd; A Sanchez; D J Bucher; J H Huffman; K Bailey; R W Sidwell
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

5.  In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201.

Authors:  R W Sidwell; D F Smee; J H Huffman; D L Barnard; K W Bailey; J D Morrey; Y S Babu
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

6.  Serum amyloid A (SAA) is an early biomarker of influenza virus disease in BALB/c, C57BL/2, Swiss-Webster, and DBA.2 mice.

Authors:  Almut H Vollmer; Makda S Gebre; Dale L Barnard
Journal:  Antiviral Res       Date:  2016-08-11       Impact factor: 5.970

7.  Effect of statin treatments on highly pathogenic avian influenza H5N1, seasonal and H1N1pdm09 virus infections in BALB/c mice.

Authors:  Yohichi Kumaki; John D Morrey; Dale L Barnard
Journal:  Future Virol       Date:  2012-08       Impact factor: 1.831

8.  Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection.

Authors:  David Verhoeven; John R Teijaro; Donna L Farber
Journal:  Virology       Date:  2009-06-02       Impact factor: 3.616

9.  A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice.

Authors:  Jamie L Fornek; Laura Gillim-Ross; Celia Santos; Victoria Carter; Jerrold M Ward; Lily I Cheng; Sean Proll; Michael G Katze; Kanta Subbarao
Journal:  J Virol       Date:  2009-08-19       Impact factor: 5.103

10.  Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.

Authors:  Kendra E Wolk; Eduardo R Lazarowski; Zachary P Traylor; Erin N Z Yu; Nancy A Jewell; Russell K Durbin; Joan E Durbin; Ian C Davis
Journal:  Am J Respir Crit Care Med       Date:  2008-08-08       Impact factor: 21.405
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