| Literature DB >> 15950058 |
R K Miller1, O Genbacev, M A Turner, J D Aplin, I Caniggia, B Huppertz.
Abstract
Placental explant cultures in vitro are useful for studying tissue functions including cellular uptake, production and release of secretory components, cell interactions, proliferation, growth and differentiation, gene delivery, pharmacology, toxicology, and disease processes. A variety of culture conditions are required to mimic in utero environments at different times of gestation including differing oxygen partial pressures, extracellular matrices and culture medium. Optimization of explant methods is examined for first and third trimester human placental tissue and the biological processes under investigation.Entities:
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Year: 2005 PMID： 15950058 DOI： 10.1016/j.placenta.2004.10.002
Source DB: PubMed Journal: Placenta ISSN： 0143-4004 Impact factor: 3.481