Literature DB >> 27527665

Placental control of drug delivery.

Sanaalarab Al-Enazy1, Shariq Ali1, Norah Albekairi2, Marwa El-Tawil3, Erik Rytting4.   

Abstract

The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream-whether from environmental contact, occupational exposure, medication, or drug abuse-the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Biotransformation; Placenta; Pregnancy; Transporters

Mesh：

Substances：

Year:  2016        PMID： 27527665      PMCID： PMC5303687          DOI： 10.1016/j.addr.2016.08.002

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  138 in total

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