Literature DB >> 15933203

A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.

Subray S Hegde1, Matthew W Vetting, Steven L Roderick, Lesley A Mitchenall, Anthony Maxwell, Howard E Takiff, John S Blanchard.   

Abstract

Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo.

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Year:  2005        PMID： 15933203     DOI： 10.1126/science.1110699

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  99 in total

1.  Protein-protein interaction networks suggest different targets have different propensities for triggering drug resistance.

Authors:  Jyothi Padiadpu; Rohit Vashisht; Nagasuma Chandra
Journal:  Syst Synth Biol       Date:  2011-02-20

2.  The 1.7 Å resolution structure of At2g44920, a pentapeptide-repeat protein in the thylakoid lumen of Arabidopsis thaliana.

Authors:  Shuisong Ni; Michael E McGookey; Stuart L Tinch; Alisha N Jones; Seetharaman Jayaraman; Liang Tong; Michael A Kennedy
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-11-25

3.  Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor.

Authors:  Subray S Hegde; Matthew W Vetting; Lesley A Mitchenall; Anthony Maxwell; John S Blanchard
Journal:  Antimicrob Agents Chemother       Date:  2010-10-11       Impact factor: 5.191

4.  Cold shock induces qnrA expression in Shewanella algae.

Authors:  Hong Bin Kim; Chi Hye Park; Mariah Gavin; George A Jacoby; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

Review 5.  A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system.

Authors:  Fernanda Maruri; Timothy R Sterling; Anne W Kaiga; Amondrea Blackman; Yuri F van der Heijden; Claudine Mayer; Emmanuelle Cambau; Alexandra Aubry
Journal:  J Antimicrob Chemother       Date:  2012-01-25       Impact factor: 5.790

6.  Pentapeptide repeat proteins.

Authors:  Matthew W Vetting; Subray S Hegde; J Eduardo Fajardo; Andras Fiser; Steven L Roderick; Howard E Takiff; John S Blanchard
Journal:  Biochemistry       Date:  2006-01-10       Impact factor: 3.162

7.  An elongated spine of buried core residues necessary for in vivo folding of the parallel beta-helix of P22 tailspike adhesin.

Authors:  Ryan Simkovsky; Jonathan King
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-27       Impact factor: 11.205

8.  Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein.

Authors:  Matthew W Vetting; Subray S Hegde; Keith Z Hazleton; John S Blanchard
Journal:  Protein Sci       Date:  2007-04       Impact factor: 6.725

9.  Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehyde.

Authors:  Matthew W Vetting; Subray S Hegde; John S Blanchard
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-04-18

10.  Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142.

Authors:  Garry W Buchko; Shuisong Ni; Howard Robinson; Eric A Welsh; Himadri B Pakrasi; Michael A Kennedy
Journal:  Protein Sci       Date:  2006-11       Impact factor: 6.725
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