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Literature DB >> 15919945

Epstein-Barr virus BZLF1 protein binds to mitotic chromosomes.

Abstract

Epstein-Barr virus (EBV) is a human herpesvirus that causes infectious mononucleosis and is associated with several types of cancers, including nasopharyngeal carcinoma and Burkitt's lymphoma. An EBV protein that plays an integral role during lytic replication is the immediate-early protein BZLF1. Our laboratory has found that BZLF1 (Z) localizes to host chromosomes during mitosis. Two Z-interacting proteins are also found localized to mitotic chromosomes in the presence of Z. The association between Z and mitotic chromosomes may lead to the sequestering of Z-interacting proteins within the cell and potentially cause an alteration of chromosome compaction or chromatin structure.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 15919945 PMCID： PMC1143656 DOI： 10.1128/JVI.79.12.7899-7904.2005

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

40 in total

1. The Epstein-Barr virus immediate-early protein BZLF1 induces both a G(2) and a mitotic block.

Authors: Amy Mauser; Elizabeth Holley-Guthrie; Dennis Simpson; William Kaufmann; Shannon Kenney
Journal: J Virol Date: 2002-10 Impact factor: 5.103

2. The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle.

Authors: C M Rooney; D T Rowe; T Ragot; P J Farrell
Journal: J Virol Date: 1989-07 Impact factor: 5.103

3. The Epstein-Barr virus (EBV) BZLF1 immediate-early gene product differentially affects latent versus productive EBV promoters.

Authors: S Kenney; J Kamine; E Holley-Guthrie; J C Lin; E C Mar; J Pagano
Journal: J Virol Date: 1989-04 Impact factor: 5.103

4. Genome rearrangements activate the Epstein-Barr virus gene whose product disrupts latency.

Authors: C Rooney; N Taylor; J Countryman; H Jenson; J Kolman; G Miller
Journal: Proc Natl Acad Sci U S A Date: 1988-12 Impact factor: 11.205

5. Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA.

Authors: J Countryman; G Miller
Journal: Proc Natl Acad Sci U S A Date: 1985-06 Impact factor: 11.205

6. trans activation of the latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment.

Authors: K Takada; N Shimizu; S Sakuma; Y Ono
Journal: J Virol Date: 1986-03 Impact factor: 5.103

7. EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx.

Authors: H zur Hausen; H Schulte-Holthausen; G Klein; W Henle; G Henle; P Clifford; L Santesson
Journal: Nature Date: 1970-12-12 Impact factor: 49.962

8. The Epstein-Barr virus immediate-early protein BZLF1 induces expression of E2F-1 and other proteins involved in cell cycle progression in primary keratinocytes and gastric carcinoma cells.

Authors: Amy Mauser; Elizabeth Holley-Guthrie; Adam Zanation; Wendall Yarborough; William Kaufmann; Aloysius Klingelhutz; William T Seaman; Shannon Kenney
Journal: J Virol Date: 2002-12 Impact factor: 5.103

9. Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter.

Authors: A Chevallier-Greco; E Manet; P Chavrier; C Mosnier; J Daillie; A Sergeant
Journal: EMBO J Date: 1986-12-01 Impact factor: 11.598

10. Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos.

Authors: P J Farrell; D T Rowe; C M Rooney; T Kouzarides
Journal: EMBO J Date: 1989-01 Impact factor: 11.598

5 in total

Review 1. How virus persistence can initiate the tumorigenesis process.

Authors: Simone Avanzi; Gualtiero Alvisi; Alessandro Ripalti
Journal: World J Virol Date: 2013-05-12

2. The B-cell-specific transcription factor and master regulator Pax5 promotes Epstein-Barr virus latency by negatively regulating the viral immediate early protein BZLF1.

Authors: Ryan M Raver; Amanda R Panfil; Stacy R Hagemeier; Shannon C Kenney
Journal: J Virol Date: 2013-05-15 Impact factor: 5.103