Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Epstein-Barr virus immediate-early protein BZLF1 induces both a G(2) and a mitotic block.

Literature DB >> 12208981

The Epstein-Barr virus immediate-early protein BZLF1 induces both a G(2) and a mitotic block.

Amy Mauser¹, Elizabeth Holley-Guthrie, Dennis Simpson, William Kaufmann, Shannon Kenney.

Abstract

The Epstein-Barr virus immediate-early protein BZLF1 is a transcriptional activator that mediates the switch from latent to lytic infection. Here we demonstrate that BZLF1 induces both a G(2) block and a mitotic block in HeLa cells and inhibits chromosome condensation. While the G(2) block is associated with decreased cyclin B1 in host cells and can be rescued by overexpression of cyclin B1, the mechanism for the mitotic defect is as yet undetermined.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12208981 PMCID： PMC136482 DOI： 10.1128/jvi.76.19.10030-10037.2002

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

45 in total

1. Infection with vaccinia virus alters regulation of cell cycle progression.

Authors: A Wali; D S Strayer
Journal: DNA Cell Biol Date: 1999-11 Impact factor: 3.311

2. Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0.

Authors: W E Hobbs; N A DeLuca
Journal: J Virol Date: 1999-10 Impact factor: 5.103

3. The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes.

Authors: S J Advani; R Brandimarti; R R Weichselbaum; B Roizman
Journal: J Virol Date: 2000-01 Impact factor: 5.103

4. Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis.

Authors: G Juan; F Traganos; W M James; J M Ray; M Roberge; D M Sauve; H Anderson; Z Darzynkiewicz
Journal: Cytometry Date: 1998-06-01

5. SV40 small T antigen enhances progression to >G2 during lytic infection.

Authors: B Whalen; J Laffin; T D Friedrich; J M Lehman
Journal: Exp Cell Res Date: 1999-08-25 Impact factor: 3.905

6. Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo.

Authors: E M Westphal; A Mauser; J Swenson; M G Davis; C L Talarico; S C Kenney
Journal: Cancer Res Date: 1999-04-01 Impact factor: 12.701

7. The Epstein-Barr virus protein BRLF1 activates S phase entry through E2F1 induction.

Authors: J J Swenson; A E Mauser; W K Kaufmann; S C Kenney
Journal: J Virol Date: 1999-08 Impact factor: 5.103

8. Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).

Authors: L Wiebusch; C Hagemeier
Journal: J Virol Date: 1999-11 Impact factor: 5.103

9. Herpes simplex virus type 1 immediate-early protein Vmw110 inhibits progression of cells through mitosis and from G(1) into S phase of the cell cycle.

Authors: P Lomonte; R D Everett
Journal: J Virol Date: 1999-11 Impact factor: 5.103

10. Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells.

Authors: P Gallant; E A Nigg
Journal: J Cell Biol Date: 1992-04 Impact factor: 10.539

19 in total

1. Mutation of a single amino acid residue in the basic region of the Epstein-Barr virus (EBV) lytic cycle switch protein Zta (BZLF1) prevents reactivation of EBV from latency.

Authors: Celine Schelcher; Sarah Valencia; Henri-Jacques Delecluse; Matthew Hicks; Alison J Sinclair
Journal: J Virol Date: 2005-11 Impact factor: 5.103

2. The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor.

Authors: Gangling Liao; Jian Huang; Elizabeth D Fixman; S Diane Hayward
Journal: J Virol Date: 2005-01 Impact factor: 5.103

3. Epstein-Barr virus BZLF1 protein binds to mitotic chromosomes.

Authors: Amy L Adamson
Journal: J Virol Date: 2005-06 Impact factor: 5.103

4. PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation.

Authors: Yaxu Wu; James E Ferguson; Hong Wang; Rusty Kelley; Rongqin Ren; Holly McDonough; James Meeker; Peter C Charles; Hengbin Wang; Cam Patterson
Journal: J Mol Cell Cardiol Date: 2007-06-30 Impact factor: 5.000

5. Contribution of C/EBP proteins to Epstein-Barr virus lytic gene expression and replication in epithelial cells.

Authors: Jian Huang; Gangling Liao; Honglin Chen; Frederick Y Wu; Lindsey Hutt-Fletcher; Gary S Hayward; S Diane Hayward
Journal: J Virol Date: 2006-02 Impact factor: 5.103

6. Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage.

Authors: Jie Yang; Wen Deng; Pok M Hau; Jia Liu; Victoria M Y Lau; Annie L M Cheung; Michael S Y Huen; Sai W Tsao
Journal: Lab Invest Date: 2015-06-01 Impact factor: 5.662

7. Modeling early Epstein-Barr virus infection in Drosophila melanogaster: the BZLF1 protein.

Authors: Amy L Adamson; Natasha Wright; Dennis R LaJeunesse
Journal: Genetics Date: 2005-08-03 Impact factor: 4.562

8. Identification of a negative regulatory element in the Epstein-Barr virus Zta transactivation domain that is regulated by the cell cycle control factors c-Myc and E2F1.

Authors: Zhen Lin; Qinyan Yin; Erik Flemington
Journal: J Virol Date: 2004-11 Impact factor: 5.103

9. Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1.

Authors: Sarah G Bailey; Elizabeth Verrall; Celine Schelcher; Alex Rhie; Aidan J Doherty; Alison J Sinclair
Journal: J Virol Date: 2009-08-05 Impact factor: 5.103

10. The zipper region of Epstein-Barr virus bZIP transcription factor Zta is necessary but not sufficient to direct DNA binding.

Authors: Matthew R Hicks; Salama S Al-Mehairi; Alison J Sinclair
Journal: J Virol Date: 2003-07 Impact factor: 5.103