Literature DB >> 2542618

The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle.

C M Rooney1, D T Rowe, T Ragot, P J Farrell.   

Abstract

A spliced cDNA spanning the Epstein-Barr virus BZLF1 gene expresses the BZLF1 protein and is active in inducing the virus productive cycle. A deletion mutant which lacks the N-terminal half of the protein is inactive. Cotransfection experiments in EBV-negative B-lymphocyte cell lines demonstrated that the BZLF1 gene activates the promoter for the BSLF2 + BMLF1 gene in the absence of any other EBV gene product. These results confirmed that the spliced BZLF1 gene is the transactivating gene structure in BamHI-Z.

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Year:  1989        PMID： 2542618      PMCID： PMC250868     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

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Authors:  L Keegan; G Gill; M Ptashne
Journal:  Science       Date:  1986-02-14       Impact factor: 47.728

2.  Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA.

Authors:  J Countryman; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

3.  Promiscuous trans activation of gene expression by an Epstein-Barr virus-encoded early nuclear protein.

Authors:  P M Lieberman; P O'Hare; G S Hayward; S D Hayward
Journal:  J Virol       Date:  1986-10       Impact factor: 5.103

4.  A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors:  F L Graham; A J van der Eb
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  DNA sequence and expression of the B95-8 Epstein-Barr virus genome.

Authors:  R Baer; A T Bankier; M D Biggin; P L Deininger; P J Farrell; T J Gibson; G Hatfull; G S Hudson; S C Satchwell; C Séguin
Journal:  Nature       Date:  1984 Jul 19-25       Impact factor: 49.962

7.  Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors:  D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal:  Nucleic Acids Res       Date:  1984-09-25       Impact factor: 16.971

8.  Palindromic structure and polypeptide expression of 36 kilobase pairs of heterogeneous Epstein-Barr virus (P3HR-1) DNA.

Authors:  H B Jenson; M S Rabson; G Miller
Journal:  J Virol       Date:  1986-05       Impact factor: 5.103

9.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

10.  Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells.

Authors:  M Rabson; L Heston; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205
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  114 in total

Review 1.  Evolutionary aspects of oncogenic herpesviruses.

Authors:  J Nicholas
Journal:  Mol Pathol       Date:  2000-10

2.  Nucleoprotein structure of immediate-early promoters Zp and Rp and of oriLyt of latent Epstein-Barr virus genomes.

Authors:  Hans Helmut Niller; Daniel Salamon; Jörg Uhlig; Stefanie Ranf; Marcus Granz; Fritz Schwarzmann; Hans Wolf; Janos Minarovits
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

3.  Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving phosphatidylinositol-3 kinase activation.

Authors:  C D Darr; A Mauser; S Kenney
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

4.  The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16.

Authors:  J M Hardwick; L Tse; N Applegren; J Nicholas; M A Veliuona
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

5.  Transcriptional synergy by the Epstein-Barr virus transactivator ZEBRA.

Authors:  M Carey; J Kolman; D A Katz; L Gradoville; L Barberis; G Miller
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

6.  The Epstein-Barr virus immediate-early promoter BRLF1 can be activated by the cellular Sp1 transcription factor.

Authors:  S Zalani; E A Holley-Guthrie; D E Gutsch; S C Kenney
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

7.  The Epstein-Barr virus (EBV) nuclear antigen 1 BamHI F promoter is activated on entry of EBV-transformed B cells into the lytic cycle.

Authors:  A L Lear; M Rowe; M G Kurilla; S Lee; S Henderson; E Kieff; A B Rickinson
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

8.  The Epstein-Barr virus immediate-early protein BZLF1 induces both a G(2) and a mitotic block.

Authors:  Amy Mauser; Elizabeth Holley-Guthrie; Dennis Simpson; William Kaufmann; Shannon Kenney
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

9.  Biophysical and mutational analysis of the putative bZIP domain of Epstein-Barr virus EBNA 3C.

Authors:  Michelle J West; Helen M Webb; Alison J Sinclair; Derek N Woolfson
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

10.  Evidence for DNA hairpin recognition by Zta at the Epstein-Barr virus origin of lytic replication.

Authors:  Andrew J Rennekamp; Pu Wang; Paul M Lieberman
Journal:  J Virol       Date:  2010-05-05       Impact factor: 5.103
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