Literature DB >> 15911570

Hardy-Weinberg testing of a single homozygous genotype.

John J Chen1, Tao Duan, Richard Single, Kristie Mather, Glenys Thomson.   

Abstract

No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed.

Mesh：

Year:  2005        PMID： 15911570      PMCID： PMC1451168          DOI： 10.1534/genetics.105.043190

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  13 in total

1.  Heterogeneous mutation processes in human microsatellite DNA sequences.

Authors:  H Ellegren
Journal:  Nat Genet       Date:  2000-04       Impact factor: 38.330

2.  Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups.

Authors:  J J Chen; J A Hollenbach; E A Trachtenberg; J J Just; M Carrington; K S Rønningen; A Begovich; M C King; S McWeeney; S J Mack; H A Erlich; G Thomson
Journal:  Tissue Antigens       Date:  1999-12

3.  Hardy-Weinberg quality control.

Authors:  I Gomes; A Collins; C Lonjou; N S Thomas; J Wilkinson; M Watson; N Morton
Journal:  Ann Hum Genet       Date:  1999-11       Impact factor: 1.670

4.  The variance for the disequilibrium coefficient in the individual Hardy-Weinberg test.

Authors:  J J Chen; G Thomson
Journal:  Biometrics       Date:  1999-12       Impact factor: 2.571

5.  A comparison of tests for Hardy-Weinberg equilibrium.

Authors:  T H Emigh
Journal:  Biometrics       Date:  1980-12       Impact factor: 2.571

6.  Performing the exact test of Hardy-Weinberg proportion for multiple alleles.

Authors:  S W Guo; E A Thompson
Journal:  Biometrics       Date:  1992-06       Impact factor: 2.571

7.  Characterization of 12 microsatellite loci of the human MHC in a panel of reference cell lines.

Authors:  M P Martin; A Harding; R Chadwick; M Kronick; M Cullen; L Lin; E Mignot; M Carrington
Journal:  Immunogenetics       Date:  1998       Impact factor: 2.846

8.  HLA DQ alpha genotype and allele frequencies in Qatari population.

Authors:  I M Sebetan; H A Hajar
Journal:  Forensic Sci Int       Date:  1997-11-10       Impact factor: 2.395

9.  An exact test for Hardy-Weinberg and multiple alleles.

Authors:  E J Louis; E R Dempster
Journal:  Biometrics       Date:  1987-12       Impact factor: 2.571

10.  Chi-squared tests with small numbers.

Authors:  C A Smith
Journal:  Ann Hum Genet       Date:  1986-05       Impact factor: 1.670
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  4 in total

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Journal:  Hum Mol Genet       Date:  2006-02-13       Impact factor: 6.150

2.  A heterozygote-homozygote test of Hardy-Weinberg equilibrium.

Authors:  Jin J Zhou; Kenneth Lange; Jeanette C Papp; Janet S Sinsheimer
Journal:  Eur J Hum Genet       Date:  2009-04-15       Impact factor: 4.246

3.  The risk of new-onset cancer associated with HFE C282Y and H63D mutations: evidence from 87,028 participants.

Authors:  Yang-Fan Lv; Xian Chang; Rui-Xi Hua; Guang-Ning Yan; Gang Meng; Xiao-Yu Liao; Xi Zhang; Qiao-Nan Guo
Journal:  J Cell Mol Med       Date:  2016-02-19       Impact factor: 5.310

4.  Detecting selection-induced departures from Hardy-Weinberg proportions.

Authors:  Joseph Lachance
Journal:  Genet Sel Evol       Date:  2009-01-21       Impact factor: 4.297
  4 in total

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