Literature DB >> 11246455

Hardy-Weinberg quality control.

I Gomes1, A Collins, C Lonjou, N S Thomas, J Wilkinson, M Watson, N Morton.   

Abstract

An efficient test of deviation from Hardy-Weinberg frequencies with one degree of freedom was applied to 44 marker loci in a genome scan, and 7 loci had a significant excess of apparent homozygotes (chi2 (1) > 6) suggestive of typing error. In this example evidence for linkage did not increase when outliers were censored. Statistical quality control is an essential part of genotyping, and the effect of mistyping and map error should be considered in evaluating any genome scan.

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Year:  1999        PMID： 11246455     DOI： 10.1017/S0003480099007824

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  38 in total

1.  The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis.

Authors:  N Maniatis; A Collins; C F Xu; L C McCarthy; D R Hewett; W Tapper; S Ennis; X Ke; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

2.  A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).

Authors:  C Lonjou; K Barnes; H Chen; W O Cookson; K A Deichmann; I P Hall; J W Holloway; T Laitinen; L J Palmer; M Wjst; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-26       Impact factor: 11.205

3.  A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study.

Authors:  James H Schick; Sudha K Iyengar; Barbara E Klein; Ronald Klein; Karlie Reading; Rachel Liptak; Christopher Millard; Kristine E Lee; Sandra C Tomany; Emily L Moore; Bonnie A Fijal; Robert C Elston
Journal:  Am J Hum Genet       Date:  2003-04-24       Impact factor: 11.025

4.  Distribution of nonrandom associations between pairs of protein loci along the third chromosome of Drosophila melanogaster.

Authors:  Carlos Zapata; Concepción Núñez; Teresa Velasco
Journal:  Genetics       Date:  2002-08       Impact factor: 4.562

5.  The number of markers in the HapMap project: some notes on chi-square and exact tests for Hardy-Weinberg equilibrium.

Authors:  Jan Graffelman
Journal:  Am J Hum Genet       Date:  2010-05-14       Impact factor: 11.025

6.  Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps.

Authors:  Weihua Zhang; Andrew Collins; Jane Gibson; William J Tapper; Sarah Hunt; Panos Deloukas; David R Bentley; Newton E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-16       Impact factor: 11.205

7.  Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905.

Authors:  L M Maier; J D Cooper; N Walker; D J Smyth; J A Todd
Journal:  Diabetologia       Date:  2005-08-13       Impact factor: 10.122

8.  Hardy-Weinberg testing of a single homozygous genotype.

Authors:  John J Chen; Tao Duan; Richard Single; Kristie Mather; Glenys Thomson
Journal:  Genetics       Date:  2005-05-23       Impact factor: 4.562

9.  A map of the human genome in linkage disequilibrium units.

Authors:  W Tapper; A Collins; J Gibson; N Maniatis; S Ennis; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-09       Impact factor: 11.205

10.  Distributions of Hardy-Weinberg equilibrium test statistics.

Authors:  R V Rohlfs; B S Weir
Journal:  Genetics       Date:  2008-09-14       Impact factor: 4.562
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