Literature DB >> 11315081

The variance for the disequilibrium coefficient in the individual Hardy-Weinberg test.

J J Chen1, G Thomson.   

Abstract

It is of interest to detect the deviation from Hardy-Weinberg proportion (HWP) for a particular heterozygote. Hernández and Weir (1989, Biometrics 45, 53-70) suggested a disequilibrium coefficient approach and proposed a 1-d.f. chi2 test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are presented.

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Year:  1999        PMID： 11315081     DOI： 10.1111/j.0006-341x.1999.01269.x

Source DB:  PubMed          Journal:  Biometrics        ISSN： 0006-341X            Impact factor:   2.571


  9 in total

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2.  Hardy-Weinberg testing of a single homozygous genotype.

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Journal:  Genetics       Date:  2005-05-23       Impact factor: 4.562

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Journal:  Diabetes Res Clin Pract       Date:  2018-09-13       Impact factor: 5.602

5.  Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan.

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Authors:  Tomader Ali Mohammed Ibrahim; Denira Govender; Mohamed Ahmed Abdullah; Janelle Annette Noble; Mohammed Osman Hussien; Julie Ann Lane; Steven John Mack; Gregory George Noble Martin; Mark Alvin Atkinson; Clive Henry Wasserfall; Graham David Ogle
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Authors:  Steven J Mack; Julia Udell; Franziska Cohen; Kazutoyo Osoegawa; Sharon K Hawbecker; David A Noonan; Martha B Ladner; Damian Goodridge; Elizabeth A Trachtenberg; Jorge R Oksenberg; Henry A Erlich
Journal:  Genes Immun       Date:  2018-01-08       Impact factor: 2.676

9.  High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility.

Authors:  Kazutoyo Osoegawa; Lisa E Creary; Gonzalo Montero-Martín; Kalyan C Mallempati; Sridevi Gangavarapu; Stacy J Caillier; Adam Santaniello; Noriko Isobe; Jill A Hollenbach; Stephen L Hauser; Jorge R Oksenberg; Marcelo A Fernández-Viňa
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  9 in total

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