Literature DB >> 15907962

Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14.

Gerhard Bringmann1, Gerhard Lang, Katja Maksimenka, Andreas Hamm, Tobias A M Gulder, Anke Dieter, Alan T Bull, James E M Stach, Niko Kocher, Werner E G Müller, Hans-Peter Fiedler.   

Abstract

The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified.

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Year:  2005        PMID： 15907962     DOI： 10.1016/j.phytochem.2005.04.010

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  9 in total

1.  Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.

Authors:  Khaled A Shaaban; Sowmyalakshmi Srinivasan; Raj Kumar; Chendil Damodaran; Jürgen Rohr
Journal:  J Nat Prod       Date:  2010-12-28       Impact factor: 4.050

2.  Highly oxygenated angucycline from Streptomyces sp. KCB15JA014.

Authors:  Gil Soo Kim; Geum Jin Kim; Byeongsan Lee; Tae Hoon Oh; Mincheol Kwon; Jung-Sook Lee; Jun-Pil Jang; Hyukjae Choi; Sung-Kyun Ko; Young-Soo Hong; Jae-Hyuk Jang; Jong Seog Ahn
Journal:  J Antibiot (Tokyo)       Date:  2020-07-10       Impact factor: 2.649

Review 3.  Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Biochim Biophys Acta       Date:  2009-03-19

4.  Kiamycin, a unique cytotoxic angucyclinone derivative from a marine Streptomyces sp.

Authors:  Zeping Xie; Bing Liu; Hongpeng Wang; Shengxiang Yang; Hongyu Zhang; Yipeng Wang; Naiyun Ji; Song Qin; Hartmut Laatsch
Journal:  Mar Drugs       Date:  2012-02-27       Impact factor: 6.085

Review 5.  Secondary Metabolites from Polar Organisms.

Authors:  Yuan Tian; Yan-Ling Li; Feng-Chun Zhao
Journal:  Mar Drugs       Date:  2017-02-23       Impact factor: 5.118

6.  Isolation, Phylogenetic and Gephyromycin Metabolites Characterization of New Exopolysaccharides-Bearing Antarctic Actinobacterium from Feces of Emperor Penguin.

Authors:  Hui-Min Gao; Peng-Fei Xie; Xiao-Ling Zhang; Qiao Yang
Journal:  Mar Drugs       Date:  2021-08-12       Impact factor: 5.118

7.  Citreobenzofuran D-F and Phomenone A-B: Five Novel Sesquiterpenoids from the Mangrove-Derived Fungus Penicillium sp. HDN13-494.

Authors:  Qian Wu; Yimin Chang; Qian Che; Dehai Li; Guojian Zhang; Tianjiao Zhu
Journal:  Mar Drugs       Date:  2022-02-13       Impact factor: 5.118

8.  Monacyclinones, New Angucyclinone Metabolites Isolated from Streptomyces sp. M7_15 Associated with the Puerto Rican Sponge Scopalina ruetzleri.

Authors:  Jan Vicente; Allison K Stewart; Ryan M van Wagoner; Elizabeth Elliott; Andrea J Bourdelais; Jeffrey L C Wright
Journal:  Mar Drugs       Date:  2015-07-29       Impact factor: 5.118

9.  Characterization of Bioactivities and Biosynthesis of Angucycline/Angucyclinone Derivatives Derived from Gephyromycinifex aptenodytis gen. nov., sp. nov.

Authors:  Wen-Zhuo Zhu; Shu-Heng Wang; Hui-Min Gao; Ya-Ming Ge; Jun Dai; Xiao-Ling Zhang; Qiao Yang
Journal:  Mar Drugs       Date:  2021-12-29       Impact factor: 5.118
  9 in total

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