| Literature DB >> 32647213 |
Gil Soo Kim1,2, Geum Jin Kim3, Byeongsan Lee1,4, Tae Hoon Oh1,4, Mincheol Kwon1,2, Jung-Sook Lee5, Jun-Pil Jang1, Hyukjae Choi3, Sung-Kyun Ko6, Young-Soo Hong1,2, Jae-Hyuk Jang7,8, Jong Seog Ahn9,10.
Abstract
LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (1), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular dichroism calculation. Compound 1 showed weak inhibitory activity against indoleamine 2,3-dioxygenase.Entities:
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Year: 2020 PMID： 32647213 DOI： 10.1038/s41429-020-0348-8
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649