Literature DB >> 15870375

Genetically engineered wine yeast produces a high concentration of L-lactic acid of extremely high optical purity.

Satoshi Saitoh1, Nobuhiro Ishida, Toru Onishi, Kenro Tokuhiro, Eiji Nagamori, Katsuhiko Kitamoto, Haruo Takahashi.   

Abstract

For mass production of lactic acid, we newly constructed a transgenic wine yeast strain that included six copies of the bovine L-lactate dehydrogenase gene on the genome. On fermentation in inexpensive cane juice-based medium, L-lactate production of this recombinant reached 122 g/liter and the optical purity was 99.9% or higher.

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Year:  2005        PMID： 15870375      PMCID： PMC1087558          DOI： 10.1128/AEM.71.5.2789-2792.2005

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  20 in total

1.  Functional replacement of the Escherichia coli D-(-)-lactate dehydrogenase gene (ldhA) with the L-(+)-lactate dehydrogenase gene (ldhL) from Pediococcus acidilactici.

Authors:  Shengde Zhou; K T Shanmugam; L O Ingram
Journal:  Appl Environ Microbiol       Date:  2003-04       Impact factor: 4.792

2.  Recombinant Escherichia coli engineered for production of L-lactic acid from hexose and pentose sugars.

Authors:  B S Dien; N N Nichols; R J Bothast
Journal:  J Ind Microbiol Biotechnol       Date:  2001-10       Impact factor: 3.346

3.  Homofermentative production of D- or L-lactate in metabolically engineered Escherichia coli RR1.

Authors:  D E Chang; H C Jung; J S Rhee; J G Pan
Journal:  Appl Environ Microbiol       Date:  1999-04       Impact factor: 4.792

4.  Metabolic engineering of Lactobacillus helveticus CNRZ32 for production of pure L-(+)-lactic acid.

Authors:  K Kylä-Nikkilä; M Hujanen; M Leisola; A Palva
Journal:  Appl Environ Microbiol       Date:  2000-09       Impact factor: 4.792

5.  Efficient production of L-(+)-lactic acid from raw starch by Streptococcus bovis 148.

Authors:  Junya Narita; Saori Nakahara; Hideki Fukuda; Akihiko Kondo
Journal:  J Biosci Bioeng       Date:  2004       Impact factor: 2.894

6.  Lactic acid production by Saccharomyces cerevisiae expressing a Rhizopus oryzae lactate dehydrogenase gene.

Authors:  Christopher D Skory
Journal:  J Ind Microbiol Biotechnol       Date:  2003-01-03       Impact factor: 3.346

7.  Development of metabolically engineered Saccharomyces cerevisiae cells for the production of lactic acid.

Authors:  D Porro; L Brambilla; B M Ranzi; E Martegani; L Alberghina
Journal:  Biotechnol Prog       Date:  1995 May-Jun

8.  Production of optically pure D-lactic acid in mineral salts medium by metabolically engineered Escherichia coli W3110.

Authors:  Shengde Zhou; T B Causey; A Hasona; K T Shanmugam; L O Ingram
Journal:  Appl Environ Microbiol       Date:  2003-01       Impact factor: 4.792

9.  Sequence and characteristics of the Bifidobacterium longum gene encoding L-lactate dehydrogenase and the primary structure of the enzyme: a new feature of the allosteric site.

Authors:  T Minowa; S Iwata; H Sakai; H Masaki; T Ohta
Journal:  Gene       Date:  1989-12-21       Impact factor: 3.688

10.  Lactic acid production by Rhizopus oryzae transformants with modified lactate dehydrogenase activity.

Authors:  C D Skory
Journal:  Appl Microbiol Biotechnol       Date:  2003-11-18       Impact factor: 4.813
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  23 in total

1.  Nuclear localization of Haa1, which is linked to its phosphorylation status, mediates lactic acid tolerance in Saccharomyces cerevisiae.

Authors:  Minetaka Sugiyama; Shin-Pei Akase; Ryota Nakanishi; Hitoshi Horie; Yoshinobu Kaneko; Satoshi Harashima
Journal:  Appl Environ Microbiol       Date:  2014-03-28       Impact factor: 4.792

2.  Efficient production of L-Lactic acid by metabolically engineered Saccharomyces cerevisiae with a genome-integrated L-lactate dehydrogenase gene.

Authors:  Nobuhiro Ishida; Satoshi Saitoh; Kenro Tokuhiro; Eiji Nagamori; Takashi Matsuyama; Katsuhiko Kitamoto; Haruo Takahashi
Journal:  Appl Environ Microbiol       Date:  2005-04       Impact factor: 4.792

Review 3.  Recombinant organisms for production of industrial products.

Authors:  Jose-Luis Adrio; Arnold L Demain
Journal:  Bioeng Bugs       Date:  2009-11-02

Review 4.  Metabolic regulation and overproduction of primary metabolites.

Authors:  Sergio Sanchez; Arnold L Demain
Journal:  Microb Biotechnol       Date:  2008-07       Impact factor: 5.813

Review 5.  Recent Advances in Lactic Acid Production by Lactic Acid Bacteria.

Authors:  Xuejiao Tian; Hao Chen; Hao Liu; Jihong Chen
Journal:  Appl Biochem Biotechnol       Date:  2021-09-14       Impact factor: 2.926

6.  Efficient production of L-lactic acid from xylose by Pichia stipitis.

Authors:  Marja Ilmén; Kari Koivuranta; Laura Ruohonen; Pirkko Suominen; Merja Penttilä
Journal:  Appl Environ Microbiol       Date:  2006-10-27       Impact factor: 4.792

7.  Physiological and transcriptional responses to high concentrations of lactic acid in anaerobic chemostat cultures of Saccharomyces cerevisiae.

Authors:  Derek A Abbott; Erwin Suir; Antonius J A van Maris; Jack T Pronk
Journal:  Appl Environ Microbiol       Date:  2008-08-01       Impact factor: 4.792

Review 8.  Progress in metabolic engineering of Saccharomyces cerevisiae.

Authors:  Elke Nevoigt
Journal:  Microbiol Mol Biol Rev       Date:  2008-09       Impact factor: 11.056

9.  Improvement of lactic acid production in Saccharomyces cerevisiae by a deletion of ssb1.

Authors:  Jinsuk J Lee; Nathan Crook; Jie Sun; Hal S Alper
Journal:  J Ind Microbiol Biotechnol       Date:  2015-12-11       Impact factor: 3.346

Review 10.  Mechanisms underlying lactic acid tolerance and its influence on lactic acid production in Saccharomyces cerevisiae.

Authors:  Arne Peetermans; María R Foulquié-Moreno; Johan M Thevelein
Journal:  Microb Cell       Date:  2021-04-14
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