| Literature DB >> 15862312 |
Vaishali Handa1, Deena Goldwater, David Stiles, Margaret Cam, George Poy, Daman Kumari, Karen Usdin.
Abstract
People with 59-200 CGG.CCG-repeats in the 5' UTR of one of their FMR1 genes are at risk for Fragile X tremor and ataxia syndrome. Females are also at risk for premature ovarian failure. These symptoms are thought to be due to the presence of the repeats at the DNA and/or RNA level. We show here that long transcribed but untranslated CGG-repeat tracts are toxic to human cells and alter the expression of a wide variety of different genes including caspase-8, CYFIP, Neurotensin and UBE3A.Entities:
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Year: 2005 PMID： 15862312 DOI： 10.1016/j.febslet.2005.04.004
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124