[Evaluation of potential damage to the regenerate during callus molding after mandibular distraction osteogenesis. Experimental study using an animal model].

BACKGROUND: Molding the regenerate created by distraction osteogenesis has clinically been shown to be an efficient lifeboat, good enough that for complex three-dimensional deformities final adjustments by molding the regenerate may be part of the treatment plan. The study assessed the limits of molding a regenerate, taking into consideration compressive and tensile forces acting simultaneously on the fresh callus.
MATERIAL AND METHODS: Distraction osteogenesis was performed in 15 beagle mandibles using custom-made devices which allowed for lengthening as well as for angulation. After linear distraction of 10 mm, a defined 20 degrees angulation was performed in one acute step. The position of the fulcrum of the device allowed the regenerate to be compressed and stretched simultaneously. The effects on bone healing were assessed after 6 or 13 weeks of consolidation and compared to a control group where only linear distraction was performed.
RESULTS: Radiological and histological investigations demonstrated that no significant difference between the biological behavior of the compressed and the stretched zone of the regenerate could be found. However, there were signs, showing the more critical character of the stretched area. After 6 weeks of consolidation, some specimens revealed delayed ossification of the stretched zone. Under stable conditions, this delay was compensated after 13 weeks of consolidation and complete osseous healing occurred.
CONCLUSIONS: Under stable conditions, a fresh regenerate can be molded to a considerable extent without endangering osseous healing permanently. Nevertheless, tensile forces acting on the regenerate should be minimized to prevent damage to the new bone. This can be achieved by overdistraction prior to callus molding or by gradually changing the vector of distraction during the lengthening process.