Literature DB >> 15853629

Imidazole and benzimidazole derivatives as chemotherapeutic agents.

Mariana Boiani1, Mercedes González.   

Abstract

Imidazole and benzimidazole systems are presented in a large number of common therapeutics agents. They were widely used in organic and medicinal chemistry, but recently the development of N-oxide derivatives got an improvement from the point of view of its chemical and biological activity. Though we will review recent developments in chemical and biological profiles (as antitumoral, antiparasitic, antiviral and antimicrobial agents) of these heterocycle systems and the corresponding N-oxides.

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Year:  2005        PMID： 15853629     DOI： 10.2174/1389557053544047

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  26 in total

1.  Anti-Candida Activity of New Azole Derivatives Alone and in Combination with Fluconazole.

Authors:  Ce Shi; Chunli Liu; Jinyan Liu; Ying Wang; Jian Li; Mingjie Xiang
Journal:  Mycopathologia       Date:  2015-05-15       Impact factor: 2.574

2.  A simple route for the synthesis of novel N-alkyl-2-(alkylthio)-1H-imidazole derivatives.

Authors:  Ebrahim Kianmehr; Narges Shamsaei Zafarghandi; Mohammad Ghanbari
Journal:  Mol Divers       Date:  2013-03-03       Impact factor: 2.943

3.  Recent progress on fluorous synthesis of biologically interesting compounds.

Authors:  Zhong-Xing Jiang; Sanjun Zhi; Wei Zhang
Journal:  Mol Divers       Date:  2014-01-20       Impact factor: 2.943

4.  1-(4-Bromo-benz-yl)-2-(4-bromo-phen-yl)-1H-benzimidazole.

Authors:  Hua-Jun Ma; Zhi-Rong Qu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-04-26

5.  Expedient on-resin synthesis of peptidic benzimidazoles.

Authors:  Michael J Bird; Anthony P Silvestri; Philip E Dawson
Journal:  Bioorg Med Chem Lett       Date:  2018-05-03       Impact factor: 2.823

6.  Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV.

Authors:  Qi Sun; Runzhi Wu; Sutang Cai; Yuan Lin; Llewlyn Sellers; Kaori Sakamoto; Biao He; Blake R Peterson
Journal:  J Med Chem       Date:  2011-02-14       Impact factor: 7.446

7.  Straightforward assembly of phenylimidazoquinoxalines via a one-pot two-step MCR process.

Authors:  Fabio De Moliner; Christopher Hulme
Journal:  Org Lett       Date:  2012-02-22       Impact factor: 6.005

8.  A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families.

Authors:  Fabio De Moliner; Christopher Hulme
Journal:  Tetrahedron Lett       Date:  2012-08-24       Impact factor: 2.415

9.  DNA Interaction Studies and In Vitro Cytotoxicity of Newly Synthesized Steroidal Imidazolidinones.

Authors:  Ayaz Mahmood Dar; Manzoor Ahmad Gatoo; Ajaz Ahmad; Mir Shabeer Ahmad; Muzaffar Hussain Najar
Journal:  J Fluoresc       Date:  2015-08-06       Impact factor: 2.217

10.  29th Annual GP2A Medicinal Chemistry Conference.

Authors:  Jean-Jacques Helesbeux; Laura Carro; Florence O McCarthy; Vânia M Moreira; Francesca Giuntini; Niamh O'Boyle; Susan E Matthews; Gülşah Bayraktar; Samuel Bertrand; Christophe Rochais; Pascal Marchand
Journal:  Pharmaceuticals (Basel)       Date:  2021-12-07
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