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Literature DB >> 24443173

Recent progress on fluorous synthesis of biologically interesting compounds.

Zhong-Xing Jiang¹, Sanjun Zhi, Wei Zhang.

Abstract

This article highlights research papers published in 2011 and 2012 on fluorous linker-assisted synthesis of biologically interesting small molecules and biomolecules.

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Year: 2014 PMID： 24443173 DOI： 10.1007/s11030-013-9503-5

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

22 in total

1. Light fluorous-tagged traceless one-pot synthesis of benzimidazoles facilitated by microwave irradiation.

Authors: Chih-Chung Tseng; Cheng-Hsun Tasi; Chung-Ming Sun
Journal: Comb Chem High Throughput Screen Date: 2012-06-01 Impact factor: 1.339

2. Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Authors: Christopher Blackburn; Cynthia Barrett; Jonathan L Blank; Frank J Bruzzese; Nancy Bump; Lawrence R Dick; Paul Fleming; Khristofer Garcia; Paul Hales; Zhigen Hu; Matthew Jones; Jane X Liu; Darshan S Sappal; Michael D Sintchak; Christopher Tsu; Kenneth M Gigstad
Journal: Bioorg Med Chem Lett Date: 2010-09-15 Impact factor: 2.823

Recent progress on fluorous synthesis of biologically interesting compounds.

1. Light fluorous-tagged traceless one-pot synthesis of benzimidazoles facilitated by microwave irradiation.

2. Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Review 3. Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006.

Review 4. Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2007.

5. Light fluorous synthesis of glucosylated glycerol teichoic acids.

Review 6. Fluorous tagging strategy for solution-phase synthesis of small molecules, peptides and oligosaccharides.

7. Fluorous linker facilitated synthesis of teichoic acid fragments.

8. Design, synthesis, and incorporation of fluorous 5-methylcytosines into oligonucleotides.

9. Visual monitoring of solid-phase extraction using chromogenic fluorous synthesis supports.

10. Phase tag-assisted synthesis of benzo[b]carbazole end-capped oligothiophenes.

1. Asymmetric solution-phase mixture aldol reaction using oligomeric ethylene glycol tagged chiral oxazolidinones.