| Literature DB >> 15776395 |
Adrian Vella1, Jason D Cooper, Christopher E Lowe, Neil Walker, Sarah Nutland, Barry Widmer, Richard Jones, Susan M Ring, Wendy McArdle, Marcus E Pembrey, David P Strachan, David B Dunger, Rebecca C J Twells, David G Clayton, John A Todd.
Abstract
As part of an ongoing search for genes associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2R alpha) of the high-affinity interleukin-2 (IL-2) receptor complex. We employed a tag single-nucleotide polymorphism (tag SNP) approach in large T1D sample collections consisting of 7,457 cases and controls and 725 multiplex families. Tag SNPs were analyzed using a multilocus test to provide a regional test for association. We found strong statistical evidence in the case-control collection (P=6.5x10(-8)) for a T1D locus in the CD25 region of chromosome 10p15 and replicated the association in the family collection (P=7.3x10(-3); combined P=1.3x10(-10)). These results illustrate the utility of tag SNPs in a chromosome-regional test of disease association and justify future fine mapping of the causal variant in the region.Entities:
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Year: 2005 PMID： 15776395 PMCID： PMC1199367 DOI： 10.1086/429843
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025