| Literature DB >> 11799396 |
Ingrid Dahlman1, Iain A Eaves, Roman Kosoy, V Anne Morrison, Joanne Heward, Stephen C L Gough, Amit Allahabadia, Jayne A Franklyn, Jaakko Tuomilehto, Eva Tuomilehto-Wolf, Francesco Cucca, Cristian Guja, Constantin Ionescu-Tirgoviste, Helen Stevens, Philippa Carr, Sarah Nutland, Patricia McKinney, Julian P Shield, William Wang, Heather J Cordell, Neil Walker, John A Todd, Patrick Concannon.
Abstract
It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.Entities:
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Year: 2002 PMID： 11799396 DOI： 10.1038/ng825
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330