Literature DB >> 15743949

The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.

Mark Albano1, Wiep Klaas Smits, Linh T Y Ho, Barbara Kraigher, Ines Mandic-Mulec, Oscar P Kuipers, David Dubnau.   

Abstract

Rok is a repressor of the transcriptional activator ComK and is therefore an important regulator of competence in Bacillus subtilis (T. T. Hoa, P. Tortosa, M. Albano, and D. Dubnau, Mol. Microbiol. 43:15-26, 2002). To address the wider role of Rok in the physiology of B. subtilis, we have used a combination of transcriptional profiling, gel shift experiments, and the analysis of lacZ fusions. We demonstrate that Rok is a repressor of a family of genes that specify membrane-localized and secreted proteins, including a number of genes that encode products with antibiotic activity. We present evidence for the recent introduction of rok into the B. subtilis-Bacillus licheniformis-Bacilllus amyloliquefaciens group by horizontal transmission.

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Year:  2005        PMID： 15743949      PMCID： PMC1064057          DOI： 10.1128/JB.187.6.2010-2019.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  34 in total

1.  Improved statistical inference from DNA microarray data using analysis of variance and a Bayesian statistical framework. Analysis of global gene expression in Escherichia coli K12.

Authors:  A D Long; H J Mangalam; B Y Chan; L Tolleri; G W Hatfield; P Baldi
Journal:  J Biol Chem       Date:  2001-03-20       Impact factor: 5.157

2.  BioProspector: discovering conserved DNA motifs in upstream regulatory regions of co-expressed genes.

Authors:  X Liu; D L Brutlag; J S Liu
Journal:  Pac Symp Biocomput       Date:  2001

3.  Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK.

Authors:  Tran Thu Hoa; Pablo Tortosa; Mark Albano; David Dubnau
Journal:  Mol Microbiol       Date:  2002-01       Impact factor: 3.501

4.  Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.

Authors:  Mitsuo Ogura; Hirotake Yamaguchi; Kazuo Kobayashi; Naotake Ogasawara; Yasutaro Fujita; Teruo Tanaka
Journal:  J Bacteriol       Date:  2002-05       Impact factor: 3.490

5.  The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK.

Authors:  Leendert W Hamoen; Daisy Kausche; Mohamed A Marahiel; Douwe van Sinderen; Gerard Venema; Pascale Serror
Journal:  FEMS Microbiol Lett       Date:  2003-01-28       Impact factor: 2.742

6.  Essential Bacillus subtilis genes.

Authors:  K Kobayashi; S D Ehrlich; A Albertini; G Amati; K K Andersen; M Arnaud; K Asai; S Ashikaga; S Aymerich; P Bessieres; F Boland; S C Brignell; S Bron; K Bunai; J Chapuis; L C Christiansen; A Danchin; M Débarbouille; E Dervyn; E Deuerling; K Devine; S K Devine; O Dreesen; J Errington; S Fillinger; S J Foster; Y Fujita; A Galizzi; R Gardan; C Eschevins; T Fukushima; K Haga; C R Harwood; M Hecker; D Hosoya; M F Hullo; H Kakeshita; D Karamata; Y Kasahara; F Kawamura; K Koga; P Koski; R Kuwana; D Imamura; M Ishimaru; S Ishikawa; I Ishio; D Le Coq; A Masson; C Mauël; R Meima; R P Mellado; A Moir; S Moriya; E Nagakawa; H Nanamiya; S Nakai; P Nygaard; M Ogura; T Ohanan; M O'Reilly; M O'Rourke; Z Pragai; H M Pooley; G Rapoport; J P Rawlins; L A Rivas; C Rivolta; A Sadaie; Y Sadaie; M Sarvas; T Sato; H H Saxild; E Scanlan; W Schumann; J F M L Seegers; J Sekiguchi; A Sekowska; S J Séror; M Simon; P Stragier; R Studer; H Takamatsu; T Tanaka; M Takeuchi; H B Thomaides; V Vagner; J M van Dijl; K Watabe; A Wipat; H Yamamoto; M Yamamoto; Y Yamamoto; K Yamane; K Yata; K Yoshida; H Yoshikawa; U Zuber; N Ogasawara
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-07       Impact factor: 11.205

7.  Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics.

Authors:  Ee-Been Goh; Grace Yim; Wayne Tsui; JoAnn McClure; Michael G Surette; Julian Davies
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-13       Impact factor: 11.205

8.  Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach.

Authors:  Leendert W Hamoen; Wiep Klaas Smits; Anne de Jong; Siger Holsappel; Oscar P Kuipers
Journal:  Nucleic Acids Res       Date:  2002-12-15       Impact factor: 16.971

9.  Microarray analysis of the Bacillus subtilis K-state: genome-wide expression changes dependent on ComK.

Authors:  Randy M Berka; Jeanette Hahn; Mark Albano; Irena Draskovic; Marjan Persuh; Xianju Cui; Alan Sloma; William Widner; David Dubnau
Journal:  Mol Microbiol       Date:  2002-03       Impact factor: 3.501

10.  Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168.

Authors:  Ronald Dorenbos; Torsten Stein; Jorrit Kabel; Claude Bruand; Albert Bolhuis; Sierd Bron; Wim J Quax; Jan Maarten Van Dijl
Journal:  J Biol Chem       Date:  2002-02-28       Impact factor: 5.157
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  42 in total

1.  The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.

Authors:  Leif Flühe; Thomas A Knappe; Michael J Gattner; Antje Schäfer; Olaf Burghaus; Uwe Linne; Mohamed A Marahiel
Journal:  Nat Chem Biol       Date:  2012-02-26       Impact factor: 15.040

2.  Global transcriptional control by NsrR in Bacillus subtilis.

Authors:  Sushma Kommineni; Amrita Lama; Benjamin Popescu; Michiko M Nakano
Journal:  J Bacteriol       Date:  2012-01-27       Impact factor: 3.490

3.  Rok regulates yuaB expression during architecturally complex colony development of Bacillus subtilis 168.

Authors:  Akos T Kovács; Oscar P Kuipers
Journal:  J Bacteriol       Date:  2010-11-19       Impact factor: 3.490

4.  Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.

Authors:  Wiep Klaas Smits; Tran Thu Hoa; Leendert W Hamoen; Oscar P Kuipers; David Dubnau
Journal:  Mol Microbiol       Date:  2007-04       Impact factor: 3.501

5.  Noise in gene expression determines cell fate in Bacillus subtilis.

Authors:  Hédia Maamar; Arjun Raj; David Dubnau
Journal:  Science       Date:  2007-06-14       Impact factor: 47.728

6.  Extracytoplasmic function sigma factors with overlapping promoter specificity regulate sublancin production in Bacillus subtilis.

Authors:  Yun Luo; John D Helmann
Journal:  J Bacteriol       Date:  2009-05-22       Impact factor: 3.490

7.  The ResD response regulator, through functional interaction with NsrR and fur, plays three distinct roles in Bacillus subtilis transcriptional control.

Authors:  Bernadette Henares; Sushma Kommineni; Onuma Chumsakul; Naotake Ogasawara; Shu Ishikawa; Michiko M Nakano
Journal:  J Bacteriol       Date:  2013-11-08       Impact factor: 3.490

8.  Characterization of YvcJ, a conserved P-loop-containing protein, and its implication in competence in Bacillus subtilis.

Authors:  Jennifer Luciano; Elodie Foulquier; Jean-Raphael Fantino; Anne Galinier; Frédérique Pompeo
Journal:  J Bacteriol       Date:  2008-12-12       Impact factor: 3.490

9.  Activity of the osmotically regulated yqiHIK promoter from Bacillus subtilis is controlled at a distance.

Authors:  Kathleen E Fischer; Erhard Bremer
Journal:  J Bacteriol       Date:  2012-07-27       Impact factor: 3.490

10.  Phenotypic and transcriptomic characterization of Bacillus subtilis mutants with grossly altered membrane composition.

Authors:  Letal I Salzberg; John D Helmann
Journal:  J Bacteriol       Date:  2008-09-26       Impact factor: 3.490
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