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Literature DB >> 11948146

Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.

Mitsuo Ogura¹, Hirotake Yamaguchi, Kazuo Kobayashi, Naotake Ogasawara, Yasutaro Fujita, Teruo Tanaka.

Abstract

The Bacillus subtilis competence transcription factor ComK is required for establishment of competence for genetic transformation. In an attempt to study the ComK factor further, we explored the genes regulated by ComK using the DNA microarray technique. In addition to the genes known to be dependent on ComK for expression, we found many genes or operons whose ComK dependence was not known previously. Among these genes, we confirmed the ComK dependence of 16 genes by using lacZ fusions, and three genes were partially dependent on ComK. Transformation efficiency was significantly reduced in an smf disruption mutant, although disruption of the other ComK-dependent genes did not result in significant decreases in transformation efficiency. Nucleotide sequences similar to that of the ComK box were found for most of the newly discovered genes regulated by ComK.

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Year: 2002 PMID： 11948146 PMCID： PMC134994 DOI： 10.1128/JB.184.9.2344-2351.2002

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

45 in total

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Journal: Mol Gen Genet Date: 1997-03-26

63 in total

1. Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach.

Authors: Leendert W Hamoen; Wiep Klaas Smits; Anne de Jong; Siger Holsappel; Oscar P Kuipers
Journal: Nucleic Acids Res Date: 2002-12-15 Impact factor: 16.971

2. Expression of transcription activator ComK of Bacillus subtilis in the heterologous host Lactococcus lactis leads to a genome-wide repression pattern: a case study of horizontal gene transfer.

Authors: Kim A Susanna; Chris D den Hengst; Leendert W Hamoen; Oscar P Kuipers
Journal: Appl Environ Microbiol Date: 2006-01 Impact factor: 4.792

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Authors: Irena Draskovic; David Dubnau
Journal: Mol Microbiol Date: 2005-02 Impact factor: 3.501

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Authors: Jeanette Hahn; Berenike Maier; Bert Jan Haijema; Michael Sheetz; David Dubnau
Journal: Cell Date: 2005-07-15 Impact factor: 41.582

5. Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.

Authors: Wiep Klaas Smits; Tran Thu Hoa; Leendert W Hamoen; Oscar P Kuipers; David Dubnau
Journal: Mol Microbiol Date: 2007-04 Impact factor: 3.501

6. A single, specific thymine mutation in the ComK-binding site severely decreases binding and transcription activation by the competence transcription factor ComK of Bacillus subtilis.

Authors: Kim A Susanna; Aleksandra M Mironczuk; Wiep Klaas Smits; Leendert W Hamoen; Oscar P Kuipers
Journal: J Bacteriol Date: 2007-04-27 Impact factor: 3.490

7. The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).

Authors: Mitsuo Ogura; Teruo Tanaka
Journal: J Bacteriol Date: 2008-11-21 Impact factor: 3.490